Document Detail

A double-blind investigation into the effects of ritodrine on uterine blood flow during the third trimester of pregnancy.
MedLine Citation:
PMID:  1108656     Owner:  NLM     Status:  MEDLINE    
The object of this double-blind crossover study was to investigate the effect of a beta-mimetic agent-ritodrine-administered intravenously at increasing infusion rates on uterine blood flow and the maternal cardiovascular system during the third trimester of normal pregnancies and pregnancies complicated by intrauterine growth retardation and/or hypertension. Uterine blood flow, maternal arterial blood pressure, maternal and fetal heart rate, and uterine activity were simultaneously recorded throughout the study. In normal pregnancies the changes in different parameters during ritodrine and placebo administration were slight. In the "pathologic" pregnancies there was a highly significant increase in maternal heart rate, differential blood pressure, and uterine blood flow during ritodrine administration. The differences in response to ritodrine and placebo were statistically significant in this later group. This study demonstrates increased sensitivity of the maternal cardiovascular system to this beta-mimetic agent in certain categories of high-risk pregnancies and possibily an increase in uteroplacental blood flow.
J P Brettes; R Renaud; R Gandar
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  124     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-03-15     Completed Date:  1976-03-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  164-8     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Clinical Trials as Topic
Fetal Diseases / drug therapy
Fetal Heart / drug effects
Heart Rate / drug effects
Pregnancy Complications, Cardiovascular / drug therapy
Pregnancy Trimester, Third
Propanolamines / pharmacology*
Regional Blood Flow / drug effects
Ritodrine / pharmacology*,  therapeutic use
Uterus / blood supply*,  drug effects
Reg. No./Substance:
0/Placebos; 0/Propanolamines; 26652-09-5/Ritodrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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