Document Detail


A double-blind gastroscopic evaluation of the effects of etodolac and naproxen on the gastrointestinal mucosa of rheumatic patients.
MedLine Citation:
PMID:  1825323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this clinical, endoscopical study was to evaluate the therapeutic efficacy and the gastric tolerability of etodolac, a new anti-inflammatory, non-steroidal drug, compared with naproxen. The study was conducted on 48 patients suffering from rheumatoid arthritis. 44 of whom completed the trial. After an initial oesophagogastroduodenoscopy to exclude the presence of gastric mucosal lesions, patients were randomly allocated to double-blind treatment with either etodolac 200 mg b.i.d. or naproxen 500 mg b.i.d. for a period of 4 weeks. Endoscopic control followed this treatment period. Both drugs proved effective in relieving clinical symptoms, without a statistically significant difference. Gastric mucosal lesions were observed in 15% of etodolac-treated patients and in 46% of patients treated with naproxen (P less than 0.05) (95% CI 0.01-0.60). Painful dyspepsia was observed in 15% of patients treated with etodolac vs. 38% of patients on naproxen therapy. This study demonstrates that etodolac is at least as active as naproxen in relieving rheumatic symptoms, and its administration results in a significantly lower degree of gastric damage.
Authors:
G Bianchi Porro; I Caruso; M Petrillo; F Montrone; S Ardizzone
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of internal medicine     Volume:  229     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-03-22     Completed Date:  1991-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  5-8     Citation Subset:  IM    
Affiliation:
Gastrointestinal Unit, L. Sacco Hospital, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*,  therapeutic use
Arthritis, Rheumatoid / drug therapy*
Double-Blind Method
Etodolac
Female
Gastric Mucosa / drug effects*
Gastroscopy
Humans
Indoleacetic Acids / adverse effects*,  therapeutic use
Intestinal Mucosa / drug effects*
Male
Middle Aged
Naproxen / adverse effects*,  therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Indoleacetic Acids; 22204-53-1/Naproxen; 41340-25-4/Etodolac

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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