Document Detail

A double-blind cross-over study of ketoprofen and phenylbutazone in rheumatoid arthritis.
MedLine Citation:
PMID:  790546     Owner:  NLM     Status:  MEDLINE    
A double-blind cross-over trial was carried out in 50 patients with definite rheumatoid arthritis, in order to compare the effects of 300 mg/day of ketoprofen with those of 600 mg/day of phenylbutazone, e.g. the maximal clinically used doses of each drug. The treatment period on each drug was two weeks. There was no statistically significant difference between the drugs with the six parameters studied, either on subjective or objective evaluation. Both drugs were superior to the conventional treatment given before the trial. The side-effects did not differ significantly for each product, except that the central nervous symptoms were less frequent with ketoprofen. Ketoprofen thus seems to be an effective and acceptable drug for the treatment of patients with rheumatoid arthritis.
P Peltola
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Scandinavian journal of rheumatology. Supplement     Volume:  1976     ISSN:  0301-3847     ISO Abbreviation:  Scand. J. Rheumatol. Suppl.     Publication Date:  1976  
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400360     Medline TA:  Scand J Rheumatol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  111-3     Citation Subset:  IM    
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MeSH Terms
Analgesics / administration & dosage,  adverse effects,  therapeutic use*
Arthritis, Rheumatoid / drug therapy*
Benzophenones / therapeutic use*
Clinical Trials as Topic
Drug Evaluation
Gastrointestinal Diseases / chemically induced
Indomethacin / administration & dosage,  therapeutic use
Ketoprofen / administration & dosage,  adverse effects,  therapeutic use*
Phenylbutazone / administration & dosage,  adverse effects,  therapeutic use*
Reg. No./Substance:
0/Analgesics; 0/Benzophenones; 22071-15-4/Ketoprofen; 50-33-9/Phenylbutazone; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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