Document Detail


A double-blind cross-over study of ketoprofen and phenylbutazone in rheumatoid arthritis.
MedLine Citation:
PMID:  790546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A double-blind cross-over trial was carried out in 50 patients with definite rheumatoid arthritis, in order to compare the effects of 300 mg/day of ketoprofen with those of 600 mg/day of phenylbutazone, e.g. the maximal clinically used doses of each drug. The treatment period on each drug was two weeks. There was no statistically significant difference between the drugs with the six parameters studied, either on subjective or objective evaluation. Both drugs were superior to the conventional treatment given before the trial. The side-effects did not differ significantly for each product, except that the central nervous symptoms were less frequent with ketoprofen. Ketoprofen thus seems to be an effective and acceptable drug for the treatment of patients with rheumatoid arthritis.
Authors:
P Peltola
Related Documents :
3874606 - Cross-sectional study of rheumatoid arthritis treatment in a university hospital.
19804006 - The use of antirheumatic disease drugs during pregnancy.
3916836 - Double-blind study with liposteroid in rheumatoid arthritis.
3811966 - Rapid hplc-determination of ibuprofen and flurbiprofen in plasma for therapeutic drug c...
7735086 - Case management applications in substance use disorders.
19912996 - The role of crf and crf-related peptides in the dark side of addiction.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Scandinavian journal of rheumatology. Supplement     Volume:  1976     ISSN:  0301-3847     ISO Abbreviation:  Scand. J. Rheumatol. Suppl.     Publication Date:  1976  
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400360     Medline TA:  Scand J Rheumatol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  111-3     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analgesics / administration & dosage,  adverse effects,  therapeutic use*
Arthritis, Rheumatoid / drug therapy*
Benzophenones / therapeutic use*
Clinical Trials as Topic
Drug Evaluation
Gastrointestinal Diseases / chemically induced
Humans
Indomethacin / administration & dosage,  therapeutic use
Ketoprofen / administration & dosage,  adverse effects,  therapeutic use*
Phenylbutazone / administration & dosage,  adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Benzophenones; 22071-15-4/Ketoprofen; 50-33-9/Phenylbutazone; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neutralizing antibodies against Escherichia coli and Vibrio cholerae enterotoxins in human milk from...
Next Document:  Clinical evaluation of ketoprofen (Orudis) in rheumatoid arthritis. Results of a multi-centre, doubl...