| A double-blind comparison of levodopa, Madopa, and Sinemet in Parkinson disease. | |
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MedLine Citation:
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PMID: 352236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A sixteen-week study examined the effect of Madopa and Sinemet on patients with Parkinson disease disease suffering nausea or vomiting as side-effects of levodopa therapy and compared the efficacy of the three preparations in controlling the symptoms of Parkinson disease. Following a control period on levodopa, 20 patients underwent four consecutive four-week regimens as follows: (1) double-blind, in which a randomized half received levodopa and half received Madopa; (2) single-blind, in which all received Madopa; (3) double-blind, in which a re-randomized half received Madopa and half Sinemet; and (4) single-blind, in which all received Sinemet. Levodopa administration via Sinemet and Madopa was held to a fixed 20% of prior levodopa dosage. Almost all patients showed great reduction in nausea and vomiting with both Madopa and Sinemet. Seventy percent of the patients showed improvement in disability compared to their levodopa baseline levels. Group means showed no difference between the improvement seen on Madopa and that seen on Sinemet. However, examination of individual responses showed that the majority of patients fared distinctly better on either Sinemet or Madopa. |
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Authors:
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S G Diamond; C H Markham; L J Treciokas |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Annals of neurology Volume: 3 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 1978 Mar |
Date Detail:
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Created Date: 1978-08-14 Completed Date: 1978-08-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 267-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Benserazide / administration & dosage*, therapeutic use Carbidopa / administration & dosage*, therapeutic use Clinical Trials as Topic Double-Blind Method Drug Combinations Female Humans Hydrazines / administration & dosage* Levodopa / administration & dosage*, adverse effects, therapeutic use Male Middle Aged Nausea / chemically induced Parkinson Disease / drug therapy* Vomiting / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Hydrazines; 0/Levodopa; 322-35-0/Benserazide; 38821-49-7/Carbidopa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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