Document Detail

A double-blind comparison of levodopa, Madopa, and Sinemet in Parkinson disease.
MedLine Citation:
PMID:  352236     Owner:  NLM     Status:  MEDLINE    
A sixteen-week study examined the effect of Madopa and Sinemet on patients with Parkinson disease disease suffering nausea or vomiting as side-effects of levodopa therapy and compared the efficacy of the three preparations in controlling the symptoms of Parkinson disease. Following a control period on levodopa, 20 patients underwent four consecutive four-week regimens as follows: (1) double-blind, in which a randomized half received levodopa and half received Madopa; (2) single-blind, in which all received Madopa; (3) double-blind, in which a re-randomized half received Madopa and half Sinemet; and (4) single-blind, in which all received Sinemet. Levodopa administration via Sinemet and Madopa was held to a fixed 20% of prior levodopa dosage. Almost all patients showed great reduction in nausea and vomiting with both Madopa and Sinemet. Seventy percent of the patients showed improvement in disability compared to their levodopa baseline levels. Group means showed no difference between the improvement seen on Madopa and that seen on Sinemet. However, examination of individual responses showed that the majority of patients fared distinctly better on either Sinemet or Madopa.
S G Diamond; C H Markham; L J Treciokas
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of neurology     Volume:  3     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
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MeSH Terms
Benserazide / administration & dosage*,  therapeutic use
Carbidopa / administration & dosage*,  therapeutic use
Clinical Trials as Topic
Double-Blind Method
Drug Combinations
Hydrazines / administration & dosage*
Levodopa / administration & dosage*,  adverse effects,  therapeutic use
Middle Aged
Nausea / chemically induced
Parkinson Disease / drug therapy*
Vomiting / chemically induced
Reg. No./Substance:
0/Drug Combinations; 0/Hydrazines; 0/Levodopa; 322-35-0/Benserazide; 38821-49-7/Carbidopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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