Document Detail


A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension.
MedLine Citation:
PMID:  359019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. A double-blind comparison of the effect of tienylic acid and hydrochlorothiazide on blood pressure was made in patients with moderate hypertension. 2. The antihypertensive effect of 500 mg tienylic acid was comparable to 100 mg hydrochlorothiazide; mean decrease in supine blood pressure after 6 weeks treatment was 20/12 mmHg with tienylic acid and 17/9 mmHg with hydrochlorothiazide. Onset of antihypertensive action was within 1 week and was associated with significant weight loss. 3. Tienylic acid caused a marked decrease in serum uric acid to a mean of 0.18 mmol/1 (n = 11, P less than 0.001), this persisted through the treatment period and returned to placebo values 1 week after treatment ceased. Some patients had uric acid crystaluria and some had post-treatment uric acid levels higher than on placebo. 4. Tineylic acid and hydrochlorothiazide caused mild hypokalemia and alkalosis with proportional decrease in plasma chloride. 5. Blood urea and serum creatinine rose with both drugs and there was an unimportant decline in plasma sodium. 6. Tienylic acid is an effective antihypertensive agent with powerful uricosuric action and appears relatively free of side effects. Further studies are necessary to determine optimal dosage regimes and long term safety.
Authors:
A H Gillies; T O Morgan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  6     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1978-12-29     Completed Date:  1978-12-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  357-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure / drug effects
Blood Urea Nitrogen
Body Weight
Carbon Dioxide / blood
Chlorides / blood
Clinical Trials as Topic
Creatinine / blood
Diuretics / therapeutic use*
Double-Blind Method
Female
Glycolates / therapeutic use*
Humans
Hydrochlorothiazide / therapeutic use*
Hypertension / drug therapy*,  physiopathology
Liver Function Tests
Male
Middle Aged
Phenoxyacetates / therapeutic use*
Phosphates / blood
Potassium / blood
Sodium / blood
Thiophenes / therapeutic use*
Uric Acid / urine
Chemical
Reg. No./Substance:
0/Chlorides; 0/Diuretics; 0/Glycolates; 0/Phenoxyacetates; 0/Phosphates; 0/Thiophenes; 124-38-9/Carbon Dioxide; 58-93-5/Hydrochlorothiazide; 60-27-5/Creatinine; 69-93-2/Uric Acid; 7440-09-7/Potassium; 7440-23-5/Sodium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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