Document Detail

A double-blind comparative study of ofloxacin otic drops versus neomycin-polymyxin B-hydrocortisone otic drops in the medical treatment of chronic suppurative otitis media.
MedLine Citation:
PMID:  8733449     Owner:  NLM     Status:  MEDLINE    
Active chronic suppurative otitis media poses a management problem when patients are being considered for surgical treatment. Topical antibiotics have demonstrated varying degrees of success in the management of discharging ears. The introduction of quinolones has revived interest in these topical agents. This double-blind study compares two antibiotics, namely ofloxacin and neomycin-polymyxin B, with similar in vitro sensitivities to Gram positive and Gram negative organisms. Fifty-two patients were selected randomly and the results show that ofloxacin eardrops have marginal benefits in symptomatic improvement (89 per cent versus 79 per cent, p = 0.27) and bacterial eradication (81 per cent versus 75 per cent, p = 0.81) in active chronic suppurative otitis media. Significantly fewer patients (seven per cent versus 29 per cent, p = 0.04) in the ofloxacin group had active disease at the end of the two-week treatment. We recommend the use of ofloxacin eardrops in managing active chronic suppurative otitis media since it has high clinical efficacy, contains no steroid component and has no demonstrated risk of ototoxicity.
M C Tong; J K Woo; C A van Hasselt
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  110     ISSN:  0022-2151     ISO Abbreviation:  J Laryngol Otol     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-10-17     Completed Date:  1996-10-17     Revised Date:  2010-07-28    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  AIM; IM    
Department of Surgery, Chinese University of Hong Kong, Shatin.
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MeSH Terms
Anti-Infective Agents / administration & dosage*,  therapeutic use
Chronic Disease
Double-Blind Method
Drug Combinations
Hydrocortisone / administration & dosage*,  therapeutic use
Instillation, Drug
Neomycin / administration & dosage*,  therapeutic use
Ofloxacin / administration & dosage*,  therapeutic use
Otitis Media, Suppurative / drug therapy*,  microbiology
Polymyxin B / administration & dosage*,  therapeutic use
Staphylococcal Infections / drug therapy
Reg. No./Substance:
0/Anti-Infective Agents; 0/Drug Combinations; 0/hydrocortisone, neomycin, polymyxin B drug combination; 1404-04-2/Neomycin; 1404-26-8/Polymyxin B; 50-23-7/Hydrocortisone; 82419-36-1/Ofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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