Document Detail

A double-blind comparative study on the contrast quality, tolerance and safety of ioversol 300 versus iohexol 300 in central venous angiography (C.V. DSA).
MedLine Citation:
PMID:  1296499     Owner:  NLM     Status:  MEDLINE    
A prospective, randomised, double-blind study was performed to test the contrast quality, tolerance and safety of ioversol 300 mg/ml (Optiray 300, Mallinckrodt Medical, Inc., St-Louis, USA) versus iohexol 300 mg/ml (Omnipaque 300, Schering AG, Berlin). The study was conducted on 80 patients with peripheral vascular disease, who underwent central venous pelvis-leg angiography. The angiograms in the ioversol group were rated "very good" and "good" in 75.6% of the cases versus 51.3% in the iohexol group. Patient tolerance was nearly identical in both groups. On the 4 point rating scale for pain and heat sensations (1 = none; 4 = severe), the average heat scores were 1.28 for ioversol and 1.44 for iohexol. None of the patients complained of pain when receiving the injection. There were clinically significant changes of blood pressure in 3 patients out of each group and tachycardia in 5 patients in the ioversol group and 9 patients in the iohexol group. Seven out of 80 patients reported mild to moderate side-effects. These were related to the contrast medium in the case of 2 patients in both the ioversol and the iohexol group. All reactions resolved spontaneously or could be controlled by treatment.
R Rieser; W Beinborn; N Ney
Related Documents :
7899799 - Efficacy of ivermectin for the treatment of head lice (pediculosis capitis).
3320709 - Relapse of duodenal ulceration after healing with omeprazole.
2979209 - Intragastric ph monitoring in acute upper gastrointestinal bleeding and the effect of i...
6375469 - Effects of flunarizine and pentoxifylline on walking distance and blood rheology in cla...
9437379 - A prospective randomized comparative trial showing that omeprazole prevents rebleeding ...
9892879 - Double-blind comparison [correction of double-blind, placebo-controlled comparison] of ...
21142749 - Impact of bevacizumab chemotherapy on craniotomy wound healing.
17415239 - A 20-year experience with the brent technique of auricular reconstruction: pearls and p...
22249089 - Outpatient blind percutaneous liver biopsy in infants and children: is it safe?
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annales de radiologie     Volume:  35     ISSN:  0003-4185     ISO Abbreviation:  Ann Radiol (Paris)     Publication Date:  1992  
Date Detail:
Created Date:  1993-04-19     Completed Date:  1993-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372331     Medline TA:  Ann Radiol (Paris)     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  311-4     Citation Subset:  IM    
Department of Radiology, Aggertalklinik, Clinic for Vascular Diseases, Engelskirchen Deutschland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Angiography / methods*
Contrast Media
Double-Blind Method
Hyperthermia, Induced
Injections, Intravenous
Iohexol / administration & dosage,  adverse effects,  diagnostic use*
Leg / blood supply,  radiography
Middle Aged
Pain / chemically induced
Pelvis / blood supply,  radiography
Triiodobenzoic Acids / administration & dosage,  adverse effects,  diagnostic use*
Reg. No./Substance:
0/Contrast Media; 0/Triiodobenzoic Acids; 66108-95-0/Iohexol; 87771-40-2/ioversol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ioversol in intravenous excretory urography. Evaluation of radiographic quality, patient tolerance a...
Next Document:  History of microsurgical reconstruction of the mandible