Document Detail

A double-blind comparative study on the contrast quality, tolerance and safety of ioversol 300 versus iohexol 300 in central venous angiography (C.V. DSA).
MedLine Citation:
PMID:  1296499     Owner:  NLM     Status:  MEDLINE    
A prospective, randomised, double-blind study was performed to test the contrast quality, tolerance and safety of ioversol 300 mg/ml (Optiray 300, Mallinckrodt Medical, Inc., St-Louis, USA) versus iohexol 300 mg/ml (Omnipaque 300, Schering AG, Berlin). The study was conducted on 80 patients with peripheral vascular disease, who underwent central venous pelvis-leg angiography. The angiograms in the ioversol group were rated "very good" and "good" in 75.6% of the cases versus 51.3% in the iohexol group. Patient tolerance was nearly identical in both groups. On the 4 point rating scale for pain and heat sensations (1 = none; 4 = severe), the average heat scores were 1.28 for ioversol and 1.44 for iohexol. None of the patients complained of pain when receiving the injection. There were clinically significant changes of blood pressure in 3 patients out of each group and tachycardia in 5 patients in the ioversol group and 9 patients in the iohexol group. Seven out of 80 patients reported mild to moderate side-effects. These were related to the contrast medium in the case of 2 patients in both the ioversol and the iohexol group. All reactions resolved spontaneously or could be controlled by treatment.
R Rieser; W Beinborn; N Ney
Related Documents :
3513329 - Effectiveness of foaming antacid in relieving induced heartburn.
16807979 - Effects of metoclopramide and ranitidine on preoperative gastric contents in day-case s...
12180579 - Effect of preoperative oral use of erythromycin and nizatidine on gastric ph and volume.
396659 - Pirenzepine versus cimetidine in the treatment of duodenal ulcer.
10650899 - Efficacy of treatment to relieve mucositis-induced discomfort.
8085509 - A randomized controlled trial of a high support hospital discharge team for elderly peo...
21678239 - Experience with the nice guidelines for imaging studies in children with first pyelonep...
20175059 - Cephalic arch stenosis in autogenous brachiocephalic hemodialysis fistulas: results of ...
19796739 - Ablation of persistent atrial fibrillation using multielectrode catheters and duty-cycl...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annales de radiologie     Volume:  35     ISSN:  0003-4185     ISO Abbreviation:  Ann Radiol (Paris)     Publication Date:  1992  
Date Detail:
Created Date:  1993-04-19     Completed Date:  1993-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372331     Medline TA:  Ann Radiol (Paris)     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  311-4     Citation Subset:  IM    
Department of Radiology, Aggertalklinik, Clinic for Vascular Diseases, Engelskirchen Deutschland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Angiography / methods*
Contrast Media
Double-Blind Method
Hyperthermia, Induced
Injections, Intravenous
Iohexol / administration & dosage,  adverse effects,  diagnostic use*
Leg / blood supply,  radiography
Middle Aged
Pain / chemically induced
Pelvis / blood supply,  radiography
Triiodobenzoic Acids / administration & dosage,  adverse effects,  diagnostic use*
Reg. No./Substance:
0/Contrast Media; 0/Triiodobenzoic Acids; 66108-95-0/Iohexol; 87771-40-2/ioversol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ioversol in intravenous excretory urography. Evaluation of radiographic quality, patient tolerance a...
Next Document:  History of microsurgical reconstruction of the mandible