Document Detail

A double abdominal aorta with a double inferior vena cava: a human congenital vascular patterning defect.
MedLine Citation:
PMID:  21538819     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Developmental abnormalities of the abdominal aorta are exceedingly rare, and the molecular mechanisms underlying these defects are unknown.
CASE: We present computed angiographic findings of a 64-year-old female with long-standing hypertension having an abdominal double aorta accompanied by a double inferior vena cava. The abdominal aorta bifurcated into two lumens just caudal to the diaphragm at the level of the 12th thoracic vertebra. The dorsal abdominal aortic trunk supplied several lumbar arteries, the inferior mesenteric artery, and both iliac arteries. The ventral abdominal aortic trunk supplied the celiac artery, both renal arteries, and the superior mesenteric artery.
CONCLUSION: We propose that a defect in the development of the aortic vascular smooth muscle is a possible mechanism for this rare anomaly based on our current understanding of the formation of the aorta during early embryonic development.
Arda Kayhan; Jack Collins; Jafar Al-Sadir; Fang Zhu; Aytekin Oto; Eric C Svensson
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-05-02
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  91     ISSN:  1542-0760     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-07     Completed Date:  2011-12-07     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  586-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
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MeSH Terms
Aorta, Abdominal / abnormalities*
Body Patterning*
Constriction, Pathologic
Hypertension / drug therapy
Middle Aged
Renal Artery / abnormalities
Tomography, X-Ray Computed
Vena Cava, Inferior / abnormalities*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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