| The dosimetry of iodine-123-labeled TISCH: a SPECT imaging agent for the D1 dopamine receptor. | |
| | |
MedLine Citation:
|
PMID: 8429338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
TISCH is an iodinated D1 specific dopamine receptor antagonist that may be useful as a SPECT imaging agent. This report documents its pharmacological safety in animals and its radiation dosimetry in humans. The dose of radiation that 123I-TISCH delivered to seven healthy subjects was estimated with the absorbed fraction technique. Conjugate images of the body were serially acquired for up to 24 hr after the administration of a known amount of activity. The count rates in the organs that could be visualized were measured on each image. These count rates were corrected for attenuation with 123I transmission scans. The doses to the other organs that did not take up enough activity to be visualized on the images were estimated with established models. The dosimetry was calculated for each subject individually before the results were averaged. Rapid biological washout minimizes the radiation exposure to most organs. The dose to the large bowel is limiting in healthy volunteers. The proximal colon receives about 0.67 rad/mCi (180 microGy/MBq) or about 5 rads for every 7.5 mCi of TISCH injected. This low radiation burden should make it feasible to study the D1 dopamine receptor in patients who have neuropsychiatric disorders before and after treatment. |
| | |
Authors:
|
P D Mozley; X Zhu; H F Kung; M H Selikson; J Hickey; S Galloway; N Pfieffer; A Alavi |
Related Documents
:
|
9098218 - Pharmacologic intervention for the diagnosis of acute cholecystitis: cholecystokinin pr... 18218428 - Reduced dose and improved image quality with a computerized line-scan radiography system. 6741698 - Image analysis of the complex of actin-tropomyosin and myosin subfragment 1. 18666818 - Application of mosfet detectors for dosimetry in small animal radiography using short e... 20355568 - Aqueous synthesis and fluorescence-imaging application of cdte/znse core/shell quantum ... 12850708 - Studies of porous media by thermally polarized gas nmr: current status. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 34 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1993 Feb |
Date Detail:
|
Created Date: 1993-03-09 Completed Date: 1993-03-09 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 208-13 Citation Subset: IM |
Affiliation:
|
Department of Radiology, University of Pennsylvania, Philadelphia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Animals Benzazepines / diagnostic use*, pharmacokinetics, toxicity Humans Iodine Radioisotopes / diagnostic use*, pharmacokinetics, toxicity Male Rabbits Radiation Dosage Receptors, Dopamine / analysis* Tissue Distribution Tomography, Emission-Computed, Single-Photon* |
| Grant Support | |
ID/Acronym/Agency:
|
MH-43880/MH/NIMH NIH HHS; NS-24538/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Benzazepines; 0/Iodine Radioisotopes; 0/Receptors, Dopamine; 131567-14-1/7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Noninvasive, real-time monitoring of renal function: the ambulatory renal monitor.
Next Document: Hepatobiliary scintigraphy in a pediatric population: determination of hepatic extraction fraction b...