Document Detail

The dose-response relationships of dipivalyl epinephrine in open-angle glaucoma.
MedLine Citation:
PMID:  305728     Owner:  NLM     Status:  MEDLINE    
The intraocular pressure responses of topically applied dipivalyl epinephrine (DPE: 0.025, 0.1, and 0.25%) were investigated in three series of open angle glaucoma patients in a double blind study. IOP responses were compared intra-individually with the effects of 1% epinephrine hydrochloride. 0.1% DPE gave an IOP reduction similar to that of 1% epinephrine-HCl. The change in IOP was less with 0.025% DPE and statistically significantly greater with 0.25% DPE when compared with the conventional epinephrine preparation. The clinical advantages of the 'pro drug' DPE are pointed out.
G K Krieglstein; W Leydhecker
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology     Volume:  205     ISSN:  0065-6100     ISO Abbreviation:  Albrecht Von Graefes Arch Klin Exp Ophthalmol     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0044637     Medline TA:  Albrecht Von Graefes Arch Klin Exp Ophthalmol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
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MeSH Terms
Dose-Response Relationship, Drug
Epinephrine / administration & dosage,  pharmacology*,  therapeutic use
Glaucoma / drug therapy
Intraocular Pressure / drug effects
Reg. No./Substance:

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