| A dose-response relationship for time to bone pain resolution after stereotactic body radiotherapy (SBRT) for renal cell carcinoma (RCC) bony metastases. | |
| | |
MedLine Citation:
|
PMID: 22248089 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background. To investigate the utility of stereotactic body radiotherapy (SBRT) in the treatment of painful renal cell carcinoma (RCC) bone metastases, and for a possible dose effect on time to symptom relief. Material and methods. Eighteen patients with 24 painful osseous lesions from metastatic RCC were treated with SBRT. The most common treatment regimens were 24 Gy in 3 fractions and 40 Gy in 5 fractions. The times from treatment to first reported pain relief and time to symptom recurrence were evaluated. Median follow-up was 38 weeks (1-156 weeks). Results. Seventy-eight percent of all patients had pain relief. Patients treated with a BED > 85 Gy achieved faster and more durable pain relief compared to those treated with a BED < 85 Gy. There was decrease in time to pain relief after a change in treatment regimen to 8 Gy × 5 fractions (BED = 86). There was only one patient with grade 1 skin toxicity. No neurological or other toxicity was observed. Conclusions. SBRT can safely and effectively treat painful RCC bony metastases. There appears to be a relationship between radiation dose and time to stable pain relief. |
| | |
Authors:
|
Pavan M Jhaveri; Bin S Teh; Arnold C Paulino; Angel I Blanco; Simon S Lo; E Brian Butler; Robert J Amato |
Related Documents
:
|
6493939 - Comparison of three cognitive strategies in altering pain behaviors on a cold pressor t... 15209969 - The effects of transcutaneous electrical nerve stimulation on experimental pain and sym... 1705999 - The threshold of pain and neurotransmitter's change on pain in parkinson's disease. 10970109 - Pain relief by various kinds of interference stimulation applied to the peripheral skin... 18164819 - Baroreflex sensitivity associated hypoalgesia in healthy states is altered by chronic p... 7877759 - A population of cells in the human thalamic principal sensory nucleus respond to painfu... 17001939 - Patients' perceptions of the impact of treatments and products on their experience of l... 2046049 - Assessing the affective component of chronic pain: development of the pain discomfort s... 21539489 - The use of ketamine in complex regional pain syndrome: possible mechanisms. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
|
Title: Acta oncologica (Stockholm, Sweden) Volume: - ISSN: 1651-226X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8709065 Medline TA: Acta Oncol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Radiology, Section of Radiation Oncology, Baylor College of Medicine , Houston, Texas , USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Three new compounds from Dictamnus dasycarpus.
Next Document: Synergistic inhibitory effect of nicotine plus oral contraceptive on mitochondrial complex-IV is med...