| The dose response relationship obtained at constant irradiation times for the induction of chromosome aberrations in human lymphocytes by cobalt-60 gamma rays. | |
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MedLine Citation:
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PMID: 6473703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The induction of unstable chromosome aberrations in human peripheral blood lymphocytes exposed in vitro to protracted doses of cobalt-60 radiation is presented. Four dose response curves have been produced using constant exposure times of 1,3,6, and 12 h. The data fit well to the linear quadratic model and the yield coefficients have been compared with those obtained for acute (less than 10 min) exposure. The quadratic coefficient is dependent on irradiation time and decreases approximately as predicted by Lea and Catcheside's G-function hypothesis. The possibility of a small proportion of much longer lived breaks is discussed. For purposes of biological dosimetry it is sufficient to assume a mean time of 2 h and a single exponential function for the repair of lesions when relating the effects of brief and protracted exposure. |
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Authors:
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D C Lloyd; A A Edwards; J S Prosser; M J Corp |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiation and environmental biophysics Volume: 23 ISSN: 0301-634X ISO Abbreviation: Radiat Environ Biophys Publication Date: 1984 |
Date Detail:
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Created Date: 1984-10-09 Completed Date: 1984-10-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0415677 Medline TA: Radiat Environ Biophys Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 179-89 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations* Cobalt Radioisotopes Dose-Response Relationship, Radiation Gamma Rays Humans Lymphocytes / radiation effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cobalt Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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