| A dose-finding study of azithromycin in the treatment of acne vulgaris. | |
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MedLine Citation:
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PMID: 17868539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This open, multicenter, comparative, randomized study included 120 subjects with papulopustular stage of acne vulgaris. Subjects were randomized to one of the three treatment groups (A, total dose 4.5 g of azithromycin in 7 weeks; B, total dose 6.0 g in 10 weeks; and C, total dose 7.5 g in 13 weeks). The aim was to identify the optimum azithromycin dose in the treatment of acne vulgaris through monitoring the efficacy and safety of three dosage regimens. Clinical efficacy was assessed upon completion of study therapy and six months of therapy initiation. Post-therapeutic efficacy assessment was available in 104 subjects. The difference between three treatment groups was most pronounced in the "cure" category (36.11% in group A, 58.82% in group B and 55.88% in group C) and "failure" category (8.33% in group A, and no failures in groups B and C). Follow up efficacy assessment was available in 87 subjects. The group percentage of "cure" was lower and group percentage of "treatment failure" higher in group A than in groups B and C. Azithromycin in a total dose of 6.0 g in 10 weeks seems to be a promising agent in the treatment of papulopustular acne vulgaris with few side effects and good patient compliance. |
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Authors:
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Aleksandra Basta-Juzbasić; Jasna Lipozencić; Lenka Oremović; Lena Kotrulja; Franjo Gruber; Ines Brajac; Dujomir Marasović; Deny Andjelinović; Lidija Herceg-Harjacek; Livija Cvitković |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Acta dermatovenerologica Croatica : ADC Volume: 15 ISSN: 1330-027X ISO Abbreviation: Acta Dermatovenerol Croat Publication Date: 2007 |
Date Detail:
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Created Date: 2007-09-17 Completed Date: 2008-01-10 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 9433781 Medline TA: Acta Dermatovenerol Croat Country: Croatia |
Other Details:
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Languages: eng Pagination: 141-7 Citation Subset: IM |
Affiliation:
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University Department of Dermatology and Venereology, Zagreb University Hospital Center and School of Medicine, Zagreb, Croatia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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drug therapy* Adolescent Adult Anti-Bacterial Agents / administration & dosage* Azithromycin / administration & dosage* Dose-Response Relationship, Drug Female Humans Male Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 83905-01-5/Azithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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