Document Detail

A dose-effect analysis of children's exposure to dental amalgam and neuropsychological function: the New England Children's Amalgam Trial.
MedLine Citation:
PMID:  17785386     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The New England Children's Amalgam Trial (NECAT) was a five-year randomized trial of 534 6- to 10-year-old children that compared the neuropsychological outcomes of those whose caries were restored using dental amalgam with the outcomes of those those whose caries were restored using mercury-free resin-based composite. The primary intention-to-treat analyses did not reveal significant differences between the treatment groups on the primary or secondary outcomes of the administered psychological tests: Full-Scale IQ score on the Wechsler Intelligence Scale for Children-Third Edition, General Memory Index of the Wide Range Assessment of Memory and Learning, and Visual-Motor Composite of the Wide Range Assessment of Visual Motor Abilities. METHODS: To determine whether treatment group assignment, a dichotomous measure of exposure, was sufficiently sensitive to detect associations between mercury exposure and these outcomes, the authors conducted analyses to evaluate the associations between the primary and secondary outcomes and two continuously distributed indexes of potential exposure, surface-years of amalgam and urinary mercury excretion. RESULTS: Neither index of mercury exposure was significantly associated with any of the three outcomes. CONCLUSIONS: The authors found no evidence that exposure to mercury from dental amalgam was associated with any adverse neuropsychological effects over the five-year period after placement of amalgam restorations. CLINICAL IMPLICATIONS: Analyses of the outcomes of the NECAT study indicate that use of dental amalgam was not associated with an increase in children's risk of experiencing neuropsychological dysfunction.
David C Bellinger; Felicia Trachtenberg; David Daniel; Annie Zhang; Mary A Tavares; Sonja McKinlay
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American Dental Association (1939)     Volume:  138     ISSN:  0002-8177     ISO Abbreviation:  J Am Dent Assoc     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-05     Completed Date:  2007-10-29     Revised Date:  2008-01-22    
Medline Journal Info:
Nlm Unique ID:  7503060     Medline TA:  J Am Dent Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1210-6     Citation Subset:  D; IM    
Children's Hospital, Boston, MA, USA.
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MeSH Terms
Analysis of Variance
Composite Resins
Dental Amalgam / adverse effects*
Dental Restoration, Permanent / methods*
Dose-Response Relationship, Drug
Intelligence / drug effects*
Intelligence Tests
Memory / drug effects*
Mercury / adverse effects,  urine
Neuropsychological Tests
Psychomotor Performance / drug effects*
Grant Support
Reg. No./Substance:
0/Composite Resins; 7439-97-6/Mercury; 8049-85-2/Dental Amalgam
Comment In:
J Am Dent Assoc. 2007 Dec;138(12):1536-7; author reply 1537   [PMID:  18056092 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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