Document Detail

The dose-dependent effects of isoflurane on outcome from severe forebrain ischemia in the rat.
MedLine Citation:
PMID:  16861426     Owner:  NLM     Status:  MEDLINE    
Isoflurane improves outcome against cerebral ischemia in the rat. However, the optimal neuroprotective concentration has not been defined. We examined the effects of different isoflurane concentrations on outcome from severe forebrain ischemia in the rat. Fasted rats were subjected to 0.5, 1.0, 1.5, 2.0, or 2.5 minimum alveolar concentration (MAC) isoflurane during 10 min bilateral carotid occlusion plus systemic hypotension. Each isoflurane concentration was administered only before ischemia. Arterial blood pressure was not pharmacologically manipulated. After ischemia, the anesthetic regimen was changed to fentanyl/nitrous oxide and maintained for 2 h. Pericranial temperature was maintained normothermic during the experiment. Neuromotor score, % dead hippocampal CA1 neurons, and cortical injury were measured 5 days postischemia. Preischemic arterial blood pressure decreased as MAC was increased. Animals administered >1.0 MAC frequently exhibited postischemic seizures resulting in increased mortality. There was no difference among MAC conditions for % dead CA1 neurons (93 approximately 95%). In the cortex, neuronal necrosis was less severe with 0.5 MAC and 1.0 MAC isoflurane relative to >1.0 MAC values. The neuromotor score in the 1.0 MAC isoflurane group was superior to the 2.5 MAC group. Dose-dependent effects of preischemic administration of isoflurane on histologic and behavioral outcome after severe forebrain ischemia were observed. Isoflurane MAC values <1.5 provided superior overall outcome relative to larger isoflurane concentrations.
Ikuko Nasu; Noriko Yokoo; Seiji Takaoka; Kosuke Takata; Tamie Hoshikawa; Masayuki Okada; Yoshihide Miura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  103     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-8, table of contents     Citation Subset:  AIM; IM    
Department of Anesthesiology, Yamagata University School of Medicine, Yamagata, Japan.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Brain Ischemia / drug therapy*
Dose-Response Relationship, Drug
Hippocampus / drug effects
Ischemic Preconditioning
Isoflurane / pharmacokinetics,  therapeutic use*
Neuroprotective Agents / therapeutic use*
Prosencephalon / blood supply*
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Neuroprotective Agents; 0/Receptors, N-Methyl-D-Aspartate; 26675-46-7/Isoflurane

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