Document Detail

The dosage of human chorionic gonadotropins influences the relationship between progesterone and cycle outcome during in vitro fertilization-embryo transfer.
MedLine Citation:
PMID:  10997481     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if the dose of hCG affects the initial rise in progesterone seen in patients undergoing IVF-ET and therefore affects it usefulness as a predictor of cycle outcome. DESIGN: Comparison of the rise in progesterone with cycle outcomes for IVF patients receiving 5,000 or 10,000 mIU hCG to stimulate oocyte maturation. SETTING: University-based infertility program. Patients-One hundred six patients undergoing IVF-ET on a long protocol of down-regulation with GnRH, hMG stimulation, and hCG to stimulate oocyte maturation. Stimulation protocol varied only in dose of hCG [5,000 mIU (N = 72) vs. 10,000 mIU (N = 34)]. MAIN OUTCOME MEASURE(S): Rise in progesterone from 12 hours before to 12 hours after hCG administration and its relationship with cycle outcome. RESULTS: All 106 women exhibited a rise in progesterone following the administration of hCG. As seen in earlier studies, there appeared to be a relationship between minimal progesterone increases (<3-fold) and cycle failure in patients receiving 5,000 mIU (P < .02). However, using the criteria of the previous study, there appears to be no relationship between progesterone and cycle outcome in patients receiving 10,000 mIU (P = .30). Further, the higher dose of hCG appeared to induce greater increases in progesterone over the 24-hour period examined (P < .02). After readjustment of the critical value to 3.5-fold, there was an increased tendency toward cycle failure in women exhibiting a minimal progesterone increase. Unlike the relationship associated with 5,000 mIU hCG, though, the relationship between 10,000 mIU hCG and progesterone levels was not statistically different (P = .10). CONCLUSIONS: Increasing the dose of hCG used to stimulate oocyte maturity shifts the previously described relationship between progesterone and IVF-ET-cycle outcome. However, while it remains unclear if progesterone can be used as a predictor of outcome at the higher hCG dose, it appears clear that a relationship exists between minimal progesterone response to hCG and cycle failure.
S D Prien; M S Canez; R H Messer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of fertility and women's medicine     Volume:  45     ISSN:  1534-892X     ISO Abbreviation:  Int J Fertil Womens Med     Publication Date:    2000 Jul-Aug
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9706778     Medline TA:  Int J Fertil Womens Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  258-63     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Embryo Transfer*
Fertilization in Vitro*
Infertility / blood,  therapy*
Ovulation Induction*
Progesterone / blood*
Time Factors
Reg. No./Substance:
0/Chorionic Gonadotropin; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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