Document Detail


The dorsomedial hypothalamic nucleus is not necessary for food-anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice.
MedLine Citation:
PMID:  19519629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circadian rhythms in mammals are regulated by a light-entrainable circadian pacemaker in the hypothalamic suprachiasmatic nucleus and food-entrainable oscillators located elsewhere in the brain and body. The dorsomedial hypothalamic nucleus (DMH) has been proposed to be the site of oscillators driving food-anticipatory circadian rhythms, but this is controversial. To further evaluate this hypothesis, we measured clock gene, temperature and activity rhythms in intact and DMH-ablated mice. A single 4-h midday feeding after an overnight fast induced mPer1 and mPer2 mRNA expression in the DMH, arcuate nucleus, nucleus of the solitary tract and area postrema, and reset daily rhythms of mPer1, mPer2 and mBMAL1 in the DMH, arcuate and neocortex. These rhythms persisted during 2 days of food deprivation after 12 days of scheduled daytime feeding. Acute induction of DMH mPer1 and mPer2 was N-methyl-D-aspartate (NMDA) receptor-dependent, whereas rhythmic expression after 6 days of restricted feeding was not. Thermal DMH lesions did not affect acute induction or rhythmic expression of clock genes in other brain regions in response to scheduled daytime feeding. DMH lesions attenuated mean daily activity levels and nocturnality but did not affect food-anticipatory rhythms of activity and body temperature in either light-dark or constant darkness. These results confirm that the DMH and other brain regions express circadian clock gene rhythms sensitive to daytime feeding schedules, but do not support the hypothesis that DMH oscillations drive food-anticipatory behavioral or temperature rhythms.
Authors:
Takahiro Moriya; Reiko Aida; Takashi Kudo; Masashi Akiyama; Masao Doi; Naomi Hayasaka; Norimichi Nakahata; Ralph Mistlberger; Hitoshi Okamura; Shigenobu Shibata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-23
Journal Detail:
Title:  The European journal of neuroscience     Volume:  29     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-06-12     Completed Date:  2009-08-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  1447-60     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan.
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MeSH Terms
Descriptor/Qualifier:
ARNTL Transcription Factors
Animals
Arcuate Nucleus / metabolism
Basic Helix-Loop-Helix Transcription Factors / genetics,  metabolism
Body Temperature / physiology*
Body Weight / physiology
Cell Cycle Proteins / genetics,  metabolism*
Circadian Rhythm / physiology*
Dorsomedial Hypothalamic Nucleus / physiology*
Feeding Behavior / physiology*
Food Deprivation / physiology
Gene Expression Regulation*
Intracellular Signaling Peptides and Proteins / genetics,  metabolism*
Male
Mice
Motor Activity / physiology
Neocortex / metabolism
Nuclear Proteins / genetics,  metabolism*
Period Circadian Proteins
Photoperiod
RNA, Messenger / genetics,  metabolism
Receptors, N-Methyl-D-Aspartate / metabolism
Solitary Nucleus / metabolism
Transcription Factors / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/ARNTL Transcription Factors; 0/ARNTL protein, human; 0/Arntl protein, mouse; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Cell Cycle Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Nuclear Proteins; 0/PER1 protein, human; 0/Per1 protein, mouse; 0/Per2 protein, mouse; 0/Period Circadian Proteins; 0/RNA, Messenger; 0/Receptors, N-Methyl-D-Aspartate; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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