Document Detail

The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4.
MedLine Citation:
PMID:  9178255     Owner:  NLM     Status:  MEDLINE    
Specific signaling molecules play a pivotal role in the induction and specification of tissues during early vertebrate embryogenesis. BMP-4 specifies ventral mesoderm differentiation and inhibits neural induction in Xenopus, whereas three molecules secreted from the organizer, noggin, follistatin and chordin dorsalize mesoderm and promote neural induction. Here we report that follistatin antagonizes the activities of BMP-4 in frog embryos and mouse teratocarcinoma cells. In Xenopus embryos follistatin blocks the ventralizing effect of BMP-4. In mouse P19 cells follistatin promotes neural differentiation. BMP-4 antagonizes the action of follistatin and prevents neural differentiation. In addition we show that the follistatin and BMP-4 proteins can interact directly in vitro. These data provide evidence that follistatin might play a role in modulating BMP-4 activity in vivo.
A Fainsod; K Deissler; R Yelin; K Marom; M Epstein; G Pillemer; H Steinbeisser; M Blum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mechanisms of development     Volume:  63     ISSN:  0925-4773     ISO Abbreviation:  Mech. Dev.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-29     Completed Date:  1997-07-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9101218     Medline TA:  Mech Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  39-50     Citation Subset:  IM    
Department of Cellular Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
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MeSH Terms
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins / antagonists & inhibitors,  physiology*
Cell Aggregation
Cell Differentiation
Embryo, Nonmammalian / anatomy & histology,  physiology*
Embryonic Induction
Gene Expression Regulation, Developmental
Glycoproteins / biosynthesis,  genetics,  physiology*
Mesoderm / cytology,  physiology
Nervous System / cytology,  embryology*
Polymerase Chain Reaction
Prolactin / pharmacology
RNA, Antisense / pharmacology
RNA, Messenger / metabolism
Tretinoin / pharmacology
Tumor Cells, Cultured
Xenopus / embryology,  genetics
Xenopus Proteins
Reg. No./Substance:
0/Bmp4 protein, mouse; 0/Bone Morphogenetic Protein 4; 0/Bone Morphogenetic Proteins; 0/Follistatin; 0/Glycoproteins; 0/RNA, Antisense; 0/RNA, Messenger; 0/Xenopus Proteins; 0/bmp4 protein, Xenopus; 302-79-4/Tretinoin; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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