Document Detail

The dorsal neural tube: a dynamic setting for cell fate decisions.
MedLine Citation:
PMID:  20683859     Owner:  NLM     Status:  MEDLINE    
The dorsal neural tube first generates neural crest cells that exit the neural primordium following an epithelial-to-mesenchymal conversion to become sympathetic ganglia, Schwann cells, dorsal root sensory ganglia, and melanocytes of the skin. Following the end of crest emigration, the dorsal midline of the neural tube becomes the roof plate, a signaling center for the organization of dorsal neuronal cell types. Recent lineage analysis performed before the onset of crest delamination revealed that the dorsal tube is a highly dynamic region sequentially traversed by fate-restricted crest progenitors. Furthermore, prospective roof plate cells were shown to originate ventral to presumptive crest and to progressively relocate dorsalward to occupy their definitive midline position following crest delamination. These data raise important questions regarding the mechanisms of cell emigration in relation to fate acquisition, and suggest the possibility that spatial and/or temporal information in the dorsal neural tube determines initial segregation of neural crest cells into their derivatives. In addition, they emphasize the need to address what controls the end of neural crest production and consequent roof plate formation, a fundamental issue for understanding the separation between central and peripheral lineages during development of the nervous system.
Shlomo Krispin; Erez Nitzan; Chaya Kalcheim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Developmental neurobiology     Volume:  70     ISSN:  1932-846X     ISO Abbreviation:  Dev Neurobiol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300215     Medline TA:  Dev Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  796-812     Citation Subset:  IM    
Copyright Information:
2010 Wiley Periodicals, Inc.
Department of Medical Neurobiology, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
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MeSH Terms
Cell Differentiation / physiology*
Cell Movement / physiology*
Ganglia, Spinal / cytology*,  growth & development
Models, Neurological
Neural Crest / cytology*,  growth & development
Neural Tube / cytology*,  growth & development
Neurons / physiology*

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