Document Detail

The dopaminuric response to high salt diet in insulin-dependent diabetes mellitus and in family history of hypertension.
MedLine Citation:
PMID:  9090656     Owner:  NLM     Status:  MEDLINE    
Alterations in the renal dopamine [DA] system have been suggested to contribute to the development of hypertension and diabetic nephropathy. To identify early abnormalities in renal handling of DA and sodium we challenged 16 normotensive patients with uncomplicated insulin-dependent diabetes (IDDM), 18 normotensive nondiabetic subjects with familial borderline hypertension, and 16 healthy controls, 14-29 years old, with a high-sodium diet (HSD). Systolic blood pressure was slightly higher in subjects with familial borderline hypertension than in the other groups on a normal sodium diet (NSD) (P < 0.05). Blood pressure and 24-h urinary measurements were performed on a NSD and after 3 days on a HSD. Twenty-four-hour urinary DA excretion was similar in all groups on NSD. A significant rise in DA excretion was noted after HSD in control subjects (P < 0.01), but not in subjects with a family history of hypertension or with IDDM. Urinary sodium excretion increased in all groups. A correlation between the change in DA and sodium/creatinine ratio after HSD was seen in healthy controls (r = 0.57, P = 0.02) but not in those with familial borderline hypertension (r = 0.18, P = 0.47) or with IDDM (r = 0.40, P = 0.15). A rise in systolic (but not diastolic) pressure was noted only in the IDDM group after HSD (P = 0.02). In conclusion, an impairment in the renal DA and sodium system can be detected early in IDDM and in individuals with familial hypertension. We speculate that this impairment may contribute to the development of hypertension and microvascular disease in both conditions.
S Rudberg; C Lemne; B Persson; A Krekula; U de Faire; A Aperia
Related Documents :
2333746 - Relation of serum and erythrocyte magnesium levels to blood pressure and a family histo...
21603136 - Testosterone increases: sodium reabsorption, blood pressure, and renal pathology in fem...
11800056 - Left ventricular structure and diastolic function in subjects with two hypertensive par...
2131266 - The effects of age, blood pressure, and knowledge of hypertensive diagnosis on anxiety ...
7889916 - Stress failure of pulmonary capillaries as a mechanism for exercise induced pulmonary h...
3173816 - Orthostatic hypotension occurring after discontinuation of long-term minoxidil therapy.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  11     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-20     Completed Date:  1997-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Department of Woman and Child Health, Karolinska Institute, St. Göran's Children's Hospital, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / drug effects,  physiology
Creatinine / urine
Diabetes Mellitus, Type 1 / physiopathology,  urine*
Dopamine / urine*
Hypertension / genetics,  physiopathology,  urine*
Sodium / urine
Sodium, Dietary / pharmacology*
Reg. No./Substance:
0/Sodium, Dietary; 60-27-5/Creatinine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Catch-up growth in children with vesico-ureteric reflux.
Next Document:  Urinary tract infections in girls: the cost-effectiveness of currently recommended investigative rou...