Document Detail

d,l-Sotalol reverses abbreviated atrial refractoriness and prevents promotion of atrial fibrillation in a canine model with left ventricular dysfunction induced by atrial tachypacing.
MedLine Citation:
PMID:  19713653     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study evaluated antiarrhythmic effects of d,l-sotalol in a canine atrial fibrillation (AF) model with left ventricular dysfunction. METHODS AND RESULTS: Thirteen beagles (Sotalol group n=7 and Control group n=6) were subjected to atrial tachypacing (ATP) (400 beats/min) with intact atrioventricular conduction for 4 weeks. Oral d,l-sotalol (2 mg/kg) was administered 1 week after starting ATP and continued throughout the experiment. One week after starting ATP, atrial effective refractory periods (AERPs) were shortened in both groups. However, d,l-sotalol treatment gradually prolonged AERP, resulting in a significant prolongation of AERP compared with the Control group at 4 weeks (Control 76 +/-4 and Sotalol 126 +/-5 ms, p<0.01). d,l-Sotalol treatment showed lower AF inducibility and shorter AF duration at 4 weeks. In the control group, expressions of L-type Ca(2+) channel alpha1c and Kv4.3 mRNA were downregulated by 46.2% and 43.0%, respectively, after 4 weeks of ATP; d,l-sotalol treatment did not affect these changes. CONCLUSIONS: d,l-Sotalol treatment prolonged AERP, even after atrial electrical remodeling had developed, and prevented AF perpetuation without affecting downregulated expression of L-type Ca(2+) channel alpha1c and Kv4.3 mRNA in an ATP-induced canine AF model.
Tamotsu Sakamoto; Akira Fujiki; Yosuke Nakatani; Masao Sakabe; Koichi Mizumaki; Norio Hashimoto; Hiroshi Inoue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-27
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-25     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1820-8     Citation Subset:  IM    
Second Department of Internal Medicine, University of Toyama, Japan.
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MeSH Terms
Action Potentials
Administration, Oral
Adrenergic beta-Antagonists / administration & dosage,  pharmacology*
Anti-Arrhythmia Agents / administration & dosage,  pharmacology*
Atrial Fibrillation / etiology,  genetics,  pathology,  physiopathology,  prevention & control*
Atrial Function / drug effects*
Calcium Channels, L-Type / genetics
Cardiac Pacing, Artificial
Disease Models, Animal
Electrophysiologic Techniques, Cardiac
Heart Atria / drug effects,  physiopathology
RNA, Messenger / metabolism
Shal Potassium Channels / genetics
Sotalol / administration & dosage,  pharmacology*
Time Factors
Ventricular Dysfunction, Left / drug therapy*,  etiology,  genetics,  pathology,  physiopathology
Ventricular Function, Left
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Calcium Channels, L-Type; 0/L-type calcium channel alpha(1C); 0/RNA, Messenger; 0/Shal Potassium Channels; 3930-20-9/Sotalol

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