Document Detail


The diving paradox: new insights into the role of the dive response in air-breathing vertebrates.
MedLine Citation:
PMID:  15313479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When aquatic reptiles, birds and mammals submerge, they typically exhibit a dive response in which breathing ceases, heart rate slows, and blood flow to peripheral tissues is reduced. The profound dive response that occurs during forced submergence sequesters blood oxygen for the brain and heart while allowing peripheral tissues to become anaerobic, thus protecting the animal from immediate asphyxiation. However, the decrease in peripheral blood flow is in direct conflict with the exercise response necessary for supporting muscle metabolism during submerged swimming. In free diving animals, a dive response still occurs, but it is less intense than during forced submergence, and whole-body metabolism remains aerobic. If blood oxygen is not sequestered for brain and heart metabolism during normal diving, then what is the purpose of the dive response? Here, we show that its primary role may be to regulate the degree of hypoxia in skeletal muscle so that blood and muscle oxygen stores can be efficiently used. Paradoxically, the muscles of diving vertebrates must become hypoxic to maximize aerobic dive duration. At the same time, morphological and enzymatic adaptations enhance intracellular oxygen diffusion at low partial pressures of oxygen. Optimizing the use of blood and muscle oxygen stores allows aquatic, air-breathing vertebrates to exercise for prolonged periods while holding their breath.
Authors:
Randall W Davis; Lori Polasek; Rebecca Watson; Amanda Fuson; Terrie M Williams; Shane B Kanatous
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  138     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-08-17     Completed Date:  2005-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-8     Citation Subset:  IM    
Affiliation:
Department of Marine Biology, Texas A&M University, 5007 Avenue U, Galveston, TX 77551, USA. davisr@tamug.tamu.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Cell Hypoxia
Diving / physiology*
Respiration*
Vertebrates / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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