Document Detail

The diversity of the effects of sulfur mustard gas inhalation on respiratory system 10 years after a single, heavy exposure: analysis of 197 cases.
MedLine Citation:
PMID:  9315808     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To find out the late pulmonary sequelae of sulfur mustard gas inhalation in 197 veterans, 10 years after their exposure. DESIGN: Cross-sectional clinical study. SETTING: University hospital. PATIENTS: One hundred ninety-seven veterans with a single, heavy exposure to sulfur mustard gas in 1986 and 86 nonexposed veterans as their control group. INTERVENTIONS: Pulmonary function tests, carbon monoxide diffusion capacity, bronchoscopy, and high-resolution CT of the chest were performed in all patients. Transbronchial lung biopsy was done in 24 suspected cases of pulmonary fibrosis. RESULTS: Asthma was diagnosed in 21 (10.65%), chronic bronchitis in 116 (58.88%), bronchiectasis in 17 (8.62%), airway narrowing due to searing or granulation tissue in 19 (9.64%), and pulmonary fibrosis in 24 (12.18%) cases. None of these were found among the control group except for a single case of chronic bronchitis. CONCLUSION: Although the respiratory symptoms of an acute sulfur mustard gas inhalation are usually transient and nonspecific, it can lead to the development of a series of chronic destructive pulmonary sequelae in such cases.
A Emad; G R Rezaian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  112     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-22     Completed Date:  1997-10-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  734-8     Citation Subset:  AIM; IM    
Department of Internal Medicine, Shiraz University of Medical Sciences, Iran.
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MeSH Terms
Airway Obstruction / chemically induced
Asthma / chemically induced
Bronchiectasis / chemically induced
Bronchitis / chemically induced
Carbon Monoxide / diagnostic use
Chemical Warfare Agents / adverse effects*
Chronic Disease
Cicatrix / chemically induced
Cross-Sectional Studies
Forced Expiratory Volume / drug effects
Granulation Tissue / drug effects,  pathology
Lung / drug effects*,  pathology,  radiography
Middle Aged
Middle East
Mustard Gas / adverse effects*
Occupational Exposure
Peak Expiratory Flow Rate / drug effects
Pulmonary Diffusing Capacity / drug effects
Pulmonary Fibrosis / chemically induced,  pathology
Respiratory Function Tests
Tomography, X-Ray Computed
Vital Capacity / drug effects
Reg. No./Substance:
0/Chemical Warfare Agents; 505-60-2/Mustard Gas; 630-08-0/Carbon Monoxide

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