| The diverse cardiac morphology seen in hearts with isomerism of the atrial appendages with reference to the disposition of the specialised conduction system. | |
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MedLine Citation:
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PMID: 16984696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congenital cardiac malformations which include isomerism of the atrial appendages are amongst the most challenging of problems for diagnosis and also for medical and surgical management. The nomenclature for pathological description is controversial, but difficulties can be overcome by the use of a segmental approach. Such an approach sets out the morphology and the topology of the chambers of the heart, together with the types and modes of the atrioventricular, ventriculo-arterial, and venous connections. We have applied this method to a study of 35 hearts known to have isomerism of the atrial appendages. We have already published accounts of 27 of these cases, but these were reviewed for this study in the light of our increased awareness of the implications of isomerism, and 8 new cases were added. After examining, or re-examining, the morphology of every heart in detail, we grouped them together according to their ventricular topology and modes of atrioventricular connection. Then we studied the course of the specialised conduction system, by the use of the light microscope, first in each individual case, and then together in their groups. We conclude that the pathways for atrioventricular conduction in hearts with isomerism of the atrial appendages are conditioned both by ventricular topology, and by the atrioventricular connections. Based on our experience, we have been able to establish guidelines that direct the clinician to the likely location of the conduction tissues. |
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Authors:
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Audrey Smith; Siew Yen Ho; Robert H Anderson; M Gwen Connell; Robert Arnold; James L Wilkinson; Andrew C Cook |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiology in the young Volume: 16 ISSN: 1047-9511 ISO Abbreviation: Cardiol Young Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-20 Completed Date: 2007-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200019 Medline TA: Cardiol Young Country: England |
Other Details:
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Languages: eng Pagination: 437-54 Citation Subset: IM |
Affiliation:
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Cardiac Unit, Institute of Child Health, University College, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Appendage
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abnormalities*,
innervation Atrioventricular Node / abnormalities* Cadaver Fetal Heart / abnormalities, innervation Heart Defects, Congenital / pathology* Heart Ventricles / innervation, pathology Humans |
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