| The diurnal variation of epidermal metabolism. | |
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MedLine Citation:
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PMID: 6890085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In previous studies, the rates of epidermal glycolysis and amino acid incorporation were found to parallel rates of mitosis in both the hypoplasia associated with starvation and the hyperplasia produced by treatment with hexadecane. To examine whether similar changes in epidermal metabolism accompany the known diurnal variation in epidermal mitotic activity, the rates of glycolysis and incorporation of amino acids in epidermal sheets from skin samples at various times during a 24-hr period were assayed. These activities were found to parallel the diurnal variation of mitosis demonstrated by metaphase counts. Diurnal variation of metabolism in the suprabasal layers was investigated by examining the relative rates of incorporation of histidine and leucine: it was found that histidine showed a broader peak of activity than that seen for the other measured activities. When epidermal samples were prepared form tissue treated with hexadecane to induce hyperplasia, an increase in metabolic activity and decrease in the amplitude of diurnal variation was observed. The results indicate that the general metabolic activities of the epidermis follow a diurnal pattern similar to that found for mitosis. |
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Authors:
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R R Harris; I C Mackenzie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 79 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 1982 Nov |
Date Detail:
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Created Date: 1982-12-18 Completed Date: 1982-12-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 283-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism Animals Cell Division Circadian Rhythm* Epidermis / metabolism* Glycolysis Histidine / metabolism Leucine / metabolism Male Mice Mice, Inbred C3H |
| Grant Support | |
ID/Acronym/Agency:
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1 R23 DE05393-02/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 61-90-5/Leucine; 71-00-1/Histidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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