Document Detail

A disturbance of gastric function in bulimia nervosa.
MedLine Citation:
PMID:  14573321     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Because the stomach plays an important role in the development of satiety, gastric function was examined in bulimia nervosa (BN). METHODS: Sixteen patients with BN and 16 controls swallowed an inflatable bag, which was positioned in the proximal stomach. Minimal distending pressure (MDP), the pressure needed to overcome intraabdominal pressure, was determined. Gastric volume was recorded after subjects drank a liquid meal. RESULTS: MDP was similar in patient and control groups (7.56 +/- 2.13 vs. 7.13 +/- 2.06 mmHg; t =.57, df = 30, p =.58). Average postmeal gastric relaxation was significantly lower in the patient group (29.7 +/- 97.8 vs. 105.1 +/- 103.3 mL; t = 2.13, df = 30, p =.042). CONCLUSIONS: Stomach relaxation following food consumption is significantly diminished in patients with BN. Physiologic abnormalities of stomach function in BN may contribute to the perpetuation of disturbances in behavior in this disorder.
B Timothy Walsh; Ellen Zimmerli; Michael J Devlin; Janet Guss; Harry R Kissileff
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  54     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-23     Completed Date:  2003-11-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-33     Citation Subset:  IM    
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA.
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MeSH Terms
Bulimia / physiopathology*
Case-Control Studies
Stomach / physiopathology*
Grant Support

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