Document Detail

The distribution of sodium salicylate in the human fetus.
MedLine Citation:
PMID:  689795     Owner:  NLM     Status:  MEDLINE    
The distribution of sodium salicylate was investigated in the fetuses of 18 mothers in the fifth or sixth month of pregnancy which had to be interrupted for medical reasons. Ninety-six min after drug administration, the salicylic acid levels in mother and fetus blood are almost equal. The highest drug levels in fetus tissue were found in the kidney, the lowest in the brain. In amniotic fluid, only traces of salicylic acid were estimated. A limited number of suitable cases made the exact statistical evaluation impossible.
J Elis; M Sechserová; J Stríbrný; J Drábková
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology and biopharmacy     Volume:  16     ISSN:  0340-0026     ISO Abbreviation:  Int J Clin Pharmacol Biopharm     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-11-18     Completed Date:  1978-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505527     Medline TA:  Int J Clin Pharmacol Biopharm     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  365-7     Citation Subset:  IM    
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MeSH Terms
Fetus / metabolism*
Maternal-Fetal Exchange
Placenta / metabolism
Pregnancy Trimester, Second
Salicylates / blood,  metabolism
Sodium Salicylate / metabolism*
Time Factors
Reg. No./Substance:
0/Salicylates; 54-21-7/Sodium Salicylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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