Document Detail

The distribution of serum albumin in human normal and degenerate articular cartilage.
MedLine Citation:
PMID:  1276178     Owner:  NLM     Status:  MEDLINE    
A method for studying the distribution of a high molecular weight solute (serum albumin) between physiological saline and human articular cartilage is described. Samples of normal and fibrillated articular cartilage from both femoral condyles and femoral heads have been studied. Limited studies have also been performed where the glycosaminoglycan content of normal cartilage has been reduced by chemical or enzymic methods. With naturally occurring cartilage a wide range of partition coefficients (0.3 to less than 0.002) was obtained. The partition coefficients are very dependent upon proteoglycan concentration, with the partition coefficient decreasing with increasing fixed charge density. An attempt is made to interpret the observed partitioning in terms of the steric exclusion by the proteoglycans.
J M Snowden; A Maroudas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  428     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  726-40     Citation Subset:  IM    
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MeSH Terms
Binding Sites
Cartilage Diseases / metabolism*
Cartilage, Articular / metabolism*
Protein Binding
Serum Albumin / isolation & purification,  metabolism*
Reg. No./Substance:
0/Serum Albumin

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