| The distribution and proliferation of the intracellular bacteria Wolbachia during spermatogenesis in Drosophila. | |
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MedLine Citation:
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PMID: 11804774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Wolbachia is a cytoplasmically inherited alpha-proteobacterium found in a wide range of host arthropod and nematode taxa. Wolbachia infection in Drosophila is closely associated with the expression of a unique form of post-fertilization lethality termed cytoplasmic incompatibility (CI). This form of incompatibility is only expressed by infected males suggesting that Wolbachia exerts its effect during spermatogenesis. The growth and distribution of Wolbachia throughout sperm development in individual spermatocysts and elongating sperm bundles is described. Wolbachia growth within a developing cyst seems to begin during the pre-meiotic spermatocyte growth phase with the majority of bacteria accumulating during cyst elongation. Wolbachia are predominantly localized in the proximal end of the immature cyst, opposite the spermatid nuclei, and throughout development there appears little movement of Wolbachia between spermatids via the connecting cytoplasmic bridges. The overall number of new cysts infected as well as the number of spermatids/cysts infected seems to decrease with age and corresponds to the previously documented drop in CI with age. In contrast, in one CI expressing line of Drosophila melanogaster, fewer cysts are infected and a much greater degree of variation in numbers is observed between spermatids. Furthermore, the initiation and extent of the fastest period of Wolbachia growth in the D. melanogaster strain lags behind that of Drosophila simulans. The possible implications on the as yet unexplained mechanism of CI are discussed. |
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Authors:
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Michael E Clark; Zoe Veneti; Kostas Bourtzis; Timothy L Karr |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mechanisms of development Volume: 111 ISSN: 0925-4773 ISO Abbreviation: Mech. Dev. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-23 Completed Date: 2002-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9101218 Medline TA: Mech Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 3-15 Citation Subset: IM |
Affiliation:
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Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cysts / microbiology Drosophila / microbiology* Drosophila melanogaster Male Spermatogenesis Testis / growth & development*, microbiology*, pathology Wolbachia / pathogenicity* |
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