Document Detail

The distribution and influence of calcitonin gene-related peptide (CGRP) on the perfusion pressure in the isolated ovarian artery in the pig.
MedLine Citation:
PMID:  15039911     Owner:  NLM     Status:  MEDLINE    
A moderate number of delicate CGRP-immunoreactive (CGRP-IR) varicose nerve terminals were found at the adventitia-media border of the sexually mature porcine ovarian artery by means of a routine single immunolabelling technique. Additionally, a pharmacological analysis was performed of the function fulfilled by alpha-CGRP and its C-terminal fragment (Tyr27) alpha-CGRP(27-37) in the porcine isolated ovarian artery, collected on days 8-13 of the oestrous cycle. It was shown that alpha-CGRP (10(-8) M) caused a decrease in the perfusion pressure of the porcine isolated ovarian artery of 16% (p < 0.05), while (Tyr27) alpha-CGRP(27-37), added at the same concentration, reduced perfusion pressure by 13% (p > 0.05). Thus, we concluded that alpha-CGRP released from perivascular terminals may cause relaxation of the ovarian artery and, furthermore, that the potency of this action is dependent on the length of the chain of this peptide produced during the deactivation of the molecule by tissue proteases.
Włodzimierz Markiewicz; Jerzy J Jaroszewski; Beata Barszczewska; Tomasz Maślanka; Mariusz Majewski
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Folia morphologica     Volume:  63     ISSN:  0015-5659     ISO Abbreviation:  Folia Morphol. (Warsz)     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-24     Completed Date:  2004-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374620     Medline TA:  Folia Morphol (Warsz)     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
Department of Pharmacology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland.
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MeSH Terms
Arteries / drug effects*,  metabolism*
Calcitonin Gene-Related Peptide / metabolism*,  pharmacology*
Estrous Cycle / physiology
Ovary / blood supply*
Regional Blood Flow / drug effects,  physiology
Vasodilation / drug effects
Reg. No./Substance:
0/calcitonin gene-related peptide (27-37):; 83652-28-2/Calcitonin Gene-Related Peptide

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