Document Detail


The distribution of fibronectin and laminin in the murine periodontal membrane, indicating possible functional roles in the apical migration of the junctional epithelium.
MedLine Citation:
PMID:  9022926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Periodontal tissue shows various morphological changes with ageing. A typical example of these changes is the apical migration of the junctional epithelium. The distribution of fibronectin and laminin was investigated by immunofluorescent and immunoelectron-microscope methods in mice to clarify any possible functional roles of these proteins in the apical migration of junctional epithelium. Apical migration begins in 20-week-old mice, and then progresses with increasing age until the mice reach 80 weeks. In the apical tip of the junctional epithelium, fibronectin was demonstrated in the sub-epithelial fibrillar matrix, preceding the progression of apical migration. Fibronectin was also demonstrated in association with the stromal side of focal contacts between epithelial cells and basement membrane. Therefore, these focal contacts are assumed to be fibronectin receptors. There was no apparent relation between the localization of laminin and the migration of the junctional epithelium. These results suggest that the fibronectin provides a provisional matrix for the apical migration of junctional epithelium, but laminin does not appear to play a major part in that migration.
Authors:
T Sakai; Y Ohsaki; M Kido; M Goto; Y Terada; H Sakai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of oral biology     Volume:  41     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:    1996 Aug-Sep
Date Detail:
Created Date:  1997-04-14     Completed Date:  1997-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  885-91     Citation Subset:  D; IM    
Affiliation:
First Department of Prosthetic Dentistry, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Cell Adhesion / physiology
Cell Movement / physiology
Chemotaxis
Epithelial Attachment / cytology*,  physiology
Extracellular Matrix / physiology
Fibronectins / analysis,  physiology*
Laminin / analysis,  physiology
Mice
Mice, Inbred C3H
Microscopy, Fluorescence
Microscopy, Immunoelectron
Periodontal Ligament / chemistry*,  physiology
Chemical
Reg. No./Substance:
0/Fibronectins; 0/Laminin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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