| The distribution of cyclooxygenase-1 in human temporomandibular joint samples: an immunohistochemical study. | |
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MedLine Citation:
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PMID: 11422676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cyclooxygenase-1,2 (COX-1,2) or prostaglandin (PG) H synthase, is the first enzyme of the pathway in which arachidonic acid is oxidized to PGs. Thus, we examined the expression of COX-1 in 16 human temporomandibular joint (TMJ) samples with internal derangement and in 10 control specimens by an immunohistological technique using paraffin-embedded tissue and specific antihuman COX-1 polyclonal antibody. There was obvious distinction of COX-1 immunoreactivity between the control specimens and internal derangement cases, at the endothelial cells and fibroblasts, in the region of posterior and/or anterior loose connective tissues and synovial membrane. The findings of the present study suggest that COX-1 might be an important mechanism for maintaining normal homeostasis at the endothelial cells and fibroblasts with internal derangement of TMJ. |
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Authors:
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H Yoshida; Y Fukumura; S Fujita; M Nishida; T Iizuka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of oral rehabilitation Volume: 28 ISSN: 0305-182X ISO Abbreviation: J Oral Rehabil Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-06-25 Completed Date: 2001-09-27 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0433604 Medline TA: J Oral Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 511-6 Citation Subset: D; IM |
Affiliation:
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Department of Oral and Maxillofacial Surgery, Fukui Prefectural Hospital, Fukui, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies / diagnostic use Arachidonic Acids / metabolism Capillaries / enzymology, pathology Connective Tissue / enzymology, pathology Cyclooxygenase 1 Dislocations / enzymology, pathology Endothelium, Vascular / enzymology, pathology Female Fibroblasts / enzymology, pathology Homeostasis / physiology Humans Immunohistochemistry Isoenzymes / analysis* Male Membrane Proteins Middle Aged Osteoarthritis / enzymology, pathology Prostaglandin-Endoperoxide Synthases / analysis* Synovial Membrane / enzymology, pathology Temporomandibular Joint / cytology, enzymology* Temporomandibular Joint Disk / enzymology, pathology Temporomandibular Joint Disorders / enzymology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Arachidonic Acids; 0/Isoenzymes; 0/Membrane Proteins; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/PTGS1 protein, human; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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