Document Detail


The distinguishing cellular features of pulmonary artery smooth muscle cells from chronic thromboembolic pulmonary hypertension patients.
MedLine Citation:
PMID:  24070262     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT In chronic thromboembolic pulmonary hypertension (CTEPH), central thrombi are the most likely disease initiators, and progressive pulmonary vascular remodeling, which is characterized by marked proliferation of pulmonary artery smooth muscle cells (PASMCs), may also contribute to the long-term progression of CTEPH. This study was designed to investigate the cellular characteristics of PASMCs isolated from the organized thrombotic tissues of CTEPH. In the present study, analysis of PASMCs isolated from five CTEPH patients and three control subjects showed that cells from CTEPH patients had certain characteristics that distinguished them from control cells, including inferior or no cell-cell contact inhibition growth, increased sensitivity to hypoxia-induced proliferation, resistance to serum starvation-induced apoptosis, and mitochondrial metabolism disorder. These differences in the PASMCs in endarterectomized tissue of CTEPH patients may prove useful in understanding the pathobiology of CTEPH.
Authors:
Lei Wang; Hui-Li Gan; Yan Liu; Song Gu; Jing Li; Li-Juan Guo; Jie Liu; Ying Wang; Yue-Xiu Wang; Zhi-Fei Zhang; Jun Wang; Chen Wang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental lung research     Volume:  39     ISSN:  1521-0499     ISO Abbreviation:  Exp. Lung Res.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  349-58     Citation Subset:  IM    
Affiliation:
1Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Chao-Yang Hospital, Capital Medical University , Beijing, P.R. China.
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