Document Detail


The distinction between lesional and non-lesional skin in psoriasis vulgaris through expression of adhesion molecules ICAM-1 and VCAM-1.
MedLine Citation:
PMID:  19022587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Psoriasis vulgaris [pv] is a systemic inflammatory skin disease affecting 2-4% population. It is well known that pv affects some parts of the skin and also whole skin as in erythrodermic form. We still do not know why in pv some parts of the skin are affected and others are not. In our hypothesis we assumed that the whole skin is in <<stand by>> position and non-lesional skin could become in every moment lesional. According to our hypothesis and also other author's research, high expression of adhesion molecules ICAM-1 and VCAM-1 in lesional as well as non-lesional skin in pv, supports this hypothesis, suggesting a significance of these molecules in pathogenesis of pv. Our hypothesis could be proved by immunohistochemical stain of ICAM-1 and VCAM-1 in lesional and non-lesional skin of pv patient in comparison with healthy skin.
Authors:
Leo Cabrijan; Tanja Batinac; Maja Lenkovic; Franjo Gruber
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Publication Detail:
Type:  Journal Article     Date:  2008-11-20
Journal Detail:
Title:  Medical hypotheses     Volume:  72     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  327-9     Citation Subset:  IM    
Affiliation:
Department of Dermatovenerology, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia. leo.cabrijan@ri.t-com.hr
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / analysis
Diagnosis, Differential
Gene Expression Profiling
Humans
Intercellular Adhesion Molecule-1 / analysis*,  metabolism*
Psoriasis / diagnosis*,  metabolism*
Skin / metabolism*
Vascular Cell Adhesion Molecule-1 / analysis*,  metabolism*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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