| A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis. | |
| | |
MedLine Citation:
|
PMID: 20682314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Macrophages are important tissue resident cells that regulate the dynamics of inflammation. However, they are strikingly heterogeneous. During studies looking at podoplanin (gp38) expression on stromal cells in the murine spleen and peritoneal cavity we unexpectedly discovered that podoplanin was expressed on a subset of F4/80(+) macrophages; a subset which we have termed fibroblastic macrophages (FM). These cells function as phagocytes in vitro as measured by bead mediated phagocytosis assays. FM also exist at high frequency in the peritoneal cavity and in zymosan induced peritonitis in vivo. These FM represent a unique subgroup of F4/80(+) macrophages and their presence in the inflamed peritoneum suggests that they play a role in zymosan induced peritonitis. |
| | |
Authors:
|
Tie Zheng Hou; Jonas Bystrom; Jonathan P Sherlock; Omar Qureshi; Sonia M Parnell; Graham Anderson; Derek W Gilroy; Christopher D Buckley |
Related Documents
:
|
1658174 - Absence of fmlp receptors on rat macrophages. 4656704 - The interaction of particulate horseradish peroxidase (hrp)-anti hrp immune complexes w... 17205294 - Pleural macrophages are the dominant cell population in the thoracic cavity with an inf... 17571804 - Effect of root canal sealers on mouse peritoneal macrophage functions. 9058774 - Linomide suppresses both th1 and th2 cytokines in experimental autoimmune myasthenia gr... 21415414 - Occludin regulates macromolecule flux across the intestinal epithelial tight junction b... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-02 |
Journal Detail:
|
Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-27 Completed Date: 2010-10-21 Revised Date: 2012-05-30 |
Medline Journal Info:
|
Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 3955-61 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
School of Immunity and Infection, MRC Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Fibroblasts / immunology* Macrophages / immunology* Membrane Glycoproteins / biosynthesis* Mice Mice, Inbred C57BL Peritonitis / chemically induced, immunology* Phagocytes / immunology* Phagocytosis* Zymosan / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
|
087520//Wellcome Trust; //Arthritis Research UK; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
0/Gp38 protein, mouse; 0/Membrane Glycoproteins; 9010-72-4/Zymosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Induction of Endosomal/lysosomal Pathways in Differentiating Osteoblasts as Revealed by Combined Pro...
Next Document: Episodic Sitewise Positive Selection on the Signal Recognition Particle Protein Ffh in Actinobacteri...