Document Detail

A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments.
MedLine Citation:
PMID:  2495000     Owner:  NLM     Status:  MEDLINE    
Tau, a microtubule-associated phosphoprotein, was identified as a definite component of paired helical filaments which progressively accumulate in Alzheimer's disease brain. To learn more about tau in the aged brain, we have isolated and sequenced a cDNA clone encoding tau from a cDNA library of an aged human brain. The cloned cDNA sequence included a new insert of 93 nucleotides, which added a fourth repeat to the three-repeat type of tau already reported. Perhaps, this four-repeat type of tau is predominant in normal aged brain. In contrast, the sequence analysis of paired helical filaments showed that the integrated tau is of three-repeat type. This indicates that a distinct form of tau is selectively incorporated into paired helical filaments.
H Mori; Y Hamada; M Kawaguchi; T Honda; J Kondo; Y Ihara
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  159     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1221-6     Citation Subset:  IM    
2nd Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / genetics,  metabolism*
Amino Acid Sequence
Base Sequence
Cerebral Cortex / metabolism
Cloning, Molecular
DNA / genetics
Microtubule-Associated Proteins / genetics*,  isolation & purification
Molecular Sequence Data
Nerve Tissue Proteins / genetics*
Reference Values
tau Proteins
Reg. No./Substance:
0/Microtubule-Associated Proteins; 0/Nerve Tissue Proteins; 0/tau Proteins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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