| The disposition of pyrimethamine in the rat isolated perfused liver: the effect of suramin. | |
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MedLine Citation:
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PMID: 2875156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetics of pyrimethamine (0.5 mg) were determined in the rat isolated perfused liver in the presence of suramin (17.75 mg). The clearance, half life, area under the curve, and volume of distribution of pyrimethamine were unaffected by the concurrent administration of suramin, as was the hepatic sub-cellular disposition of the drug. This report is of relevance to the future concurrent administration of suramin and pyrimethamine in West Africa. |
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Authors:
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M D Coleman; K Adjepon-Yamoah |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 38 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-09-29 Completed Date: 1986-09-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 531-2 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Half-Life Kinetics Liver / drug effects, metabolism* Male Pyrimethamine / metabolism* Rats Suramin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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145-63-1/Suramin; 58-14-0/Pyrimethamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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