Document Detail


The disposition and metabolism of I.C.I. 58,834 (viloxazine) in humans.
MedLine Citation:
PMID:  1154799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. 2-(2-Ethoxyphenoxymethyl)-2,3,5,6-tetrahydro-1,4-oxazine (I.C.I. 58,834) in three 14C-labelled forms, given orally to two male volunteers, was completely absorbed, extensively metabolized and rapidly eliminated via the kidney. 2. O-Dealkylation, the major metabolic pathway in the rat, was not significant in man. 3. The major component in blood at all times was I.C.I. 58,834, which had a blood half-life of 4 h. The level of 14C in blood at 31 h was near the limit of detection. 4. The observed activity of the drug appears to be due to the parent compound alone.
Authors:
D E Case; P R Reeves
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  5     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-11-06     Completed Date:  1975-11-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  113-29     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Antidepressive Agents / metabolism*
Carbon Radioisotopes
Chemical Phenomena
Chemistry
Chromatography, Paper
Chromatography, Thin Layer
Feces / metabolism
Humans
Magnetic Resonance Spectroscopy
Male
Oxazines / blood,  metabolism*,  urine
Time Factors
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 0/Carbon Radioisotopes; 0/Oxazines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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