Document Detail


The disposition of [14C]metronidazole in rats following vaginal and oral administration.
MedLine Citation:
PMID:  39996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The absorption, tissue distribution and excretion of [17C]metronidazole (14C-MTZ) were compared during the first 4 h after administration of 10 mg kg-1 of 14C-MTZ either orally or intravaginally (i.v.g.) to rats. Peak 14C blood concentrations were reached at 1 h in both groups. Blood samples collected at 0.5, 3 and 4 h had a higher 14C concentration in orally dosed rats (P less than 0.05) than in i.v.g.-treated animals. About 3% of the i.v.g. applied dose remained in the vagina at 4 h. After 4 h, the plasma, liver, kidney, brain, lung and uterus concentrations of 14C were similar in both groups, whereas the blood, skeletal muscle and fat 14C values were significantly greater in the orally dosed rats. The total recoveries of 14C in the urine and faeces did not differ (ca 38% over 4 h) between the two groups. These results suggest that the kinetics of metronidazole are similar after the administration of equal amounts of this drug by either route.
Authors:
H S Buttar; W H Siddiqui; J H Moffatt
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  31     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  542-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Feces / analysis
Female
Metronidazole / administration & dosage,  metabolism*
Rats
Time Factors
Tissue Distribution
Vagina
Chemical
Reg. No./Substance:
443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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