Document Detail


The diseases treated with ECMO: focus on PPHN.
MedLine Citation:
PMID:  15921147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal extracorporeal support is most often required for neonatal hypoxemic respiratory failure, usually accompanied by persistent pulmonary hypertension of the newborn (PPHN). PPHN is a clinical syndrome that results from the failure of pulmonary vascular transition to extrauterine life. Infants typically present shortly after birth with respiratory distress and cyanosis, but a structurally normal heart. The incidence of PPHN is estimated at 0.2% of live-born term infants. Respiratory failure and hypoxemia in the term newborn result from a heterogeneous group of disorders, and the therapeutic approach and response often depend on the underlying disease. PPHN can largely be thought of as one of three types: (1) the abnormally constricted pulmonary vasculature which is the most common type and includes diagnoses such as meconium aspiration syndrome, respiratory distress syndrome, and sepsis; (2) the structurally abnormal vasculature, which is often termed idiopathic PPHN; or (3) the hypoplastic vasculature such as is seen in congenital diaphragmatic hernia, or alveolar capillary dysplasia, a rare malformation of lung development. The pathophysiology of each type is dependent on the point in gestation when the normal transition to extrauterine life fails. This article will discuss the known pathophysiology in PPHN and new treatment modalities.
Authors:
Kathryn N Farrow; Paola Fliman; Robin H Steinhorn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  29     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-05-30     Completed Date:  2005-09-13     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Extracorporeal Membrane Oxygenation*
Humans
Hypertension, Pulmonary / etiology,  physiopathology*,  therapy*
Infant, Newborn
Lung / blood supply*,  embryology,  growth & development
Nitric Oxide / administration & dosage
Respiratory Distress Syndrome, Newborn / physiopathology,  therapy
Respiratory Insufficiency / physiopathology,  therapy
Vasodilator Agents / administration & dosage
Grant Support
ID/Acronym/Agency:
L40 HD045314/HD/NICHD NIH HHS; R01 HL054705/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 31C4KY9ESH/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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