| The disease resistance signaling components EDS1 and PAD4 are essential regulators of the cell death pathway controlled by LSD1 in Arabidopsis. | |
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MedLine Citation:
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PMID: 11595797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Specific recognition of pathogens is mediated by plant disease resistance (R) genes and translated into a successful defense response. The extent of associated hypersensitive cell death varies from none to an area encompassing cells surrounding an infection site, depending on the R gene activated. We constructed double mutants in Arabidopsis between positive regulators of R function and a negative regulator of cell death, LSD1, to address whether genes required for normal R function also regulate the runaway cell death observed in lsd1 mutants. We report here that EDS1 and PAD4, two signaling genes that mediate some but not all R responses, also are required for runaway cell death in the lsd1 mutant. Importantly, this novel function of EDS1 and PAD4 is operative when runaway cell death in lsd1 is initiated through an R gene that does not require EDS1 or PAD4 for disease resistance. NDR1, another component of R signaling, also contributes to the control of plant cell death. The roles of EDS1 and PAD4 in regulating lsd1 runaway cell death are related to the interpretation of reactive oxygen intermediate-derived signals at infection sites. We further demonstrate that the fate of superoxide at infection sites is different from that observed at the leading margins of runaway cell death lesions in lsd1 mutants. |
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Authors:
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C Rustérucci; D H Aviv; B F Holt; J L Dangl; J E Parker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Plant cell Volume: 13 ISSN: 1040-4651 ISO Abbreviation: Plant Cell Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-11 Completed Date: 2002-01-28 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 9208688 Medline TA: Plant Cell Country: United States |
Other Details:
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Languages: eng Pagination: 2211-24 Citation Subset: IM |
Affiliation:
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Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arabidopsis
/
cytology,
genetics,
growth & development,
physiology* Arabidopsis Proteins* Carboxylic Ester Hydrolases / genetics* Cell Death DNA-Binding Proteins / genetics*, metabolism* Gene Expression Regulation, Plant* Immunity, Innate Plant Diseases* Plant Leaves / physiology Signal Transduction Transcription Factors / metabolism* Zinc Fingers |
| Grant Support | |
ID/Acronym/Agency:
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5RO1-GM057171-01/GM/NIGMS NIH HHS; GM07092-26/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Arabidopsis Proteins; 0/DNA-Binding Proteins; 0/EDS1 protein, Arabidopsis; 0/LSD1 protein, Arabidopsis; 0/Transcription Factors; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.-/PAD4 protein, Arabidopsis |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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