Document Detail

A discriminant function for preeclampsia: case-control study of minor hemoglobins, red cell enzymes, and clinical laboratory values.
MedLine Citation:
PMID:  9259948     Owner:  NLM     Status:  MEDLINE    
A case-control study was performed in eight pairs of women to determine whether preeclamptic women developed abnormalities in minor hemoglobins, glycolytic enzymes, or other blood components that might provide insight into the pathophysiology of preeclampsia, or that in combination might be used as a marker for the condition. These variables and standard clinical tests were analyzed as discriminators between preeclamptic and control women. The subjects were matched for age, ethnicity, parity, and gestational age. Blood samples were taken at the time of diagnosis of preeclampsia and at comparable gestational ages for matched normal controls. Variables differing significantly between groups included increases in uric acid (UA), low-density lipoproteins (LDL), phosphoglycerate kinase (PGK), and mean platelet volume (MPV), and decreases in glyceraldehyde phosphate dehydrogenase (G3PD) in preeclamptic women compared to normal controls. Discriminant analysis revealed the following function to separate the groups: 0.7764 (UA) + 0.8086 (PGK) -0.7032 (G3PD) + 0.1399 (LDL) -0.2386 (MPV). A discriminant score of > or = 275 indicated a > or = 90% probability of preeclampsia. The results are consistent with perturbations in red cell glycolysis in preeclampsia. Further prospective studies are warranted to test the efficacy of this discriminant function in predicting preeclampsia.
K P Braun; N F Gant; C M Olson; V Parisi; K A Forrest; C M Peterson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of perinatology     Volume:  14     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-09-04     Completed Date:  1997-09-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  297-302     Citation Subset:  IM    
Sansum Medical Research Foundation, Santa Barbara, California 93105, USA.
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MeSH Terms
Biological Markers / blood
Case-Control Studies
Chromatography, Ion Exchange
Discriminant Analysis
Erythrocytes / enzymology*
Gestational Age
Glyceraldehyde-3-Phosphate Dehydrogenases / blood
Hemoglobins / metabolism*
Infant, Newborn
Lipoproteins, LDL / blood
Middle Aged
Phosphoglycerate Kinase / blood
Pre-Eclampsia / blood*,  diagnosis,  etiology
Predictive Value of Tests
Pregnancy Outcome
Uric Acid / blood
Reg. No./Substance:
0/Biological Markers; 0/Hemoglobins; 0/Lipoproteins, LDL; 69-93-2/Uric Acid; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases; EC Kinase
Comment In:
Am J Perinatol. 1998 Jan;15(1):1-2   [PMID:  9475678 ]

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