| The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. | |
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MedLine Citation:
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PMID: 10987424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cyclic peptide ANP 4-23 and the linear peptide analogue AP-811 have been shown to be selective ANP-CR antagonists. Via alanine scanning and truncation studies we sought to determine which residues in these molecules were important in their binding to the clearance receptor and the relationship between these two molecules. These studies show that several modifications to these compounds are possible which improve physical properties of these molecules while retaining high affinity for the ANP-CR. |
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Authors:
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C A Veale; V C Alford; D Aharony; D L Banville; R A Bialecki; F J Brown; J R Damewood; C L Dantzman; P D Edwards; R T Jacobs; R C Mauger; M M Murphy; W Palmer; K K Pine; W L Rumsey; L E Garcia-Davenport; A Shaw; G B Steelman; J M Surian; E P Vacek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 10 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2001-01-04 Completed Date: 2001-01-04 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1949-52 Citation Subset: IM |
Affiliation:
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Department of Chemistry, AstraZeneca Pharmaceuticals, Wilmington, DE 19850-5437, USA. chris.veale@astrazeneca.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Atrial Natriuretic Factor / metabolism* Molecular Sequence Data Receptors, Atrial Natriuretic Factor / antagonists & inhibitors* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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85637-73-6/Atrial Natriuretic Factor; EC 4.6.1.2/Receptors, Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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