Document Detail


A discordant twin study of premorbid cognitive ability in schizophrenia.
MedLine Citation:
PMID:  16484094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twin studies are advantageous because sources of genetic and environmental variation are equated in ways that are not possible in standard case-control designs. We examined premorbid cognitive ability by comparing Armed Forces Qualification Test scores administered at the time of military enlistment in 21 schizophrenia-discordant twin pairs and 860 matched control twins. Scores were significantly lower in schizophrenia probands than in their nonpsychotic co-twins; co-twins were midway between probands and control twins. Effects were reduced when the discordant pairs were extended to include 33 psychosis-discordant pairs. Compared with controls, education at enlistment was significantly lower in psychosis probands and in co-twins from both schizophrenia- and psychosis-disordant pairs. Co-twins from psychosis-discordant pairs had significantly lower education at midlife than controls. Results suggest that cognitive ability is influenced by familial vulnerability for schizophrenia or psychosis, and that premorbid cognitive ability is lower in schizophrenia versus psychosis in general. Educational advancement may be slightly slowed by this familial vulnerability, but results were equivocal with regard to attenuation of one's ultimate educational attainment.
Authors:
William S Kremen; Michael J Lyons; Corwin Boake; Hong Xian; Kristen C Jacobson; Brian Waterman; Seth A Eisen; Jack Goldberg; Stephen V Faraone; Ming T Tsuang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Twin Study    
Journal Detail:
Title:  Journal of clinical and experimental neuropsychology     Volume:  28     ISSN:  1380-3395     ISO Abbreviation:  J Clin Exp Neuropsychol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-17     Completed Date:  2006-04-14     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  8502170     Medline TA:  J Clin Exp Neuropsychol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  208-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Case-Control Studies
Cognition Disorders / diagnosis*,  epidemiology*
Humans
Middle Aged
Neuropsychological Tests
Schizophrenia / epidemiology*
Severity of Illness Index
Time Factors
Twins, Dizygotic*
Grant Support
ID/Acronym/Agency:
AA10586/AA/NIAAA NIH HHS; AG18386-012A1/AG/NIA NIH HHS; AG18386-012A2/AG/NIA NIH HHS; DA04604/DA/NIDA NIH HHS; R01 AG018386/AG/NIA NIH HHS

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