Document Detail


ON direction-selective ganglion cells in the mouse retina.
MedLine Citation:
PMID:  16901944     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two types of ganglion cells (RGCs) compute motion direction in the retina: the ON-OFF direction-selective ganglion cells (DSGCs) and the ON DSGCs. The ON DSGCs are much less studied mostly due to the low encounter rate. In this study, we investigated the physiology, dendritic morphology and synaptic inputs of the ON DSGCs in the mouse retina. When a visual stimulus moved back and forth in the preferred-null axis, we found that the ON DSGCs exhibited a larger EPSC when the visual stimulus moved in the preferred direction and a larger IPSC in the opposite, or null direction, similar to what has been found in ON-OFF DSGCs. This similar synaptic input pattern is in contrast to other well-known differences, namely: profile of velocity sensitivity, distribution of preferred directions, and different central projection of the axons. Immunohistochemical staining showed that the dendrites of ON DSGCs exhibited tight cofasciculation with the cholinergic plexus. These findings suggest that cholinergic amacrine cells may play an important role in generating direction selectivity in the ON DSGCs, and that the mechanism for coding motion direction is probably similar for the two types of DSGCs in the retina.
Authors:
Wenzhi Sun; Qiudong Deng; William R Levick; Shigang He
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-10
Journal Detail:
Title:  The Journal of physiology     Volume:  576     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-03     Completed Date:  2006-11-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 15 Da-tun Road, Beijing 100101, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholinergic Fibers / physiology
Electrophysiology*
Excitatory Postsynaptic Potentials / physiology
Membrane Potentials / physiology
Mice
Mice, Inbred C57BL
Neural Inhibition / physiology
Patch-Clamp Techniques
Retinal Ganglion Cells / physiology*
Synapses / physiology
Synaptic Transmission / physiology*
Comments/Corrections

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