| ON direction-selective ganglion cells in the mouse retina. | |
| | |
MedLine Citation:
|
PMID: 16901944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Two types of ganglion cells (RGCs) compute motion direction in the retina: the ON-OFF direction-selective ganglion cells (DSGCs) and the ON DSGCs. The ON DSGCs are much less studied mostly due to the low encounter rate. In this study, we investigated the physiology, dendritic morphology and synaptic inputs of the ON DSGCs in the mouse retina. When a visual stimulus moved back and forth in the preferred-null axis, we found that the ON DSGCs exhibited a larger EPSC when the visual stimulus moved in the preferred direction and a larger IPSC in the opposite, or null direction, similar to what has been found in ON-OFF DSGCs. This similar synaptic input pattern is in contrast to other well-known differences, namely: profile of velocity sensitivity, distribution of preferred directions, and different central projection of the axons. Immunohistochemical staining showed that the dendrites of ON DSGCs exhibited tight cofasciculation with the cholinergic plexus. These findings suggest that cholinergic amacrine cells may play an important role in generating direction selectivity in the ON DSGCs, and that the mechanism for coding motion direction is probably similar for the two types of DSGCs in the retina. |
| | |
Authors:
|
Wenzhi Sun; Qiudong Deng; William R Levick; Shigang He |
Related Documents
:
|
21045564 - Rostral migratory stream neuroblasts turn and change directions in stereotypic patterns. 8106914 - Detection of vorticity in optical flow fields. 22535084 - 10m/500mbps wdm visible light communication systems. 487064 - Seaward orientation of hatchling turtles: turning systems in the optic tectum. 4067014 - The optokinetic nystagmus and ocular pigmentation of hypopigmented mouse mutants. 21659024 - A symmetric motion estimation method for motion-compensated frame interpolation. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-08-10 |
Journal Detail:
|
Title: The Journal of physiology Volume: 576 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-10-03 Completed Date: 2006-11-30 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
|
Languages: eng Pagination: 197-202 Citation Subset: IM |
Affiliation:
|
State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 15 Da-tun Road, Beijing 100101, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cholinergic Fibers / physiology Electrophysiology* Excitatory Postsynaptic Potentials / physiology Membrane Potentials / physiology Mice Mice, Inbred C57BL Neural Inhibition / physiology Patch-Clamp Techniques Retinal Ganglion Cells / physiology* Synapses / physiology Synaptic Transmission / physiology* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Monocarboxylate transporter 1 (MCT1) plays a direct role in short-chain fatty acids absorption in ca...
Next Document: Central chemoreceptors and sympathetic vasomotor outflow.