Document Detail


The direct effects of propofol on pial microvessels in rabbits.
MedLine Citation:
PMID:  19098622     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Propofol is widely used for neurosurgical anesthesia; however, its effects on the pial microvasculature are unknown. We therefore evaluated the direct effects of propofol on pial microvessels in rabbits. Pial microcirculation was visualized using a closed cranial window technique in 20 Japanese white rabbits. In the first experiment (n=14), after baseline hemodynamic measurements, the cranial window was superfused with 5 increasing concentrations of propofol (10, 10, 10, 10, 10 mol/L; n=8) or intralipid (at comparable concentrations; n=6) dissolved in artificial cerebrospinal fluid for 7 minutes each. A typical anesthetic concentration of 5 microg/mL corresponds to 10 mol/L. In the second experiment (n=6), phenylephrine 10 mol/L and nitroglycerin 10 mol/L were applied topically for 7 minutes under pentobarbital anesthesia. In the third experiment (n=3), electroencephalogram and bispectral index were measured under pentobarbital anesthesia. Diameters of selected pial arterioles and venules were visualized with a microscope-video capture unit combination and subsequently measured with a digital video analyzer. Topical application of propofol at 10, 10, 10, or 10 mol/L did not alter the diameters of the pial microvessels; however, at 10 mol/L propofol induced dilation in large and small arterioles, along with venular dilation. Intralipid alone did not have any significant effect on vessel diameters. Phenylephrine and nitroglycerin produced pial arteriolar and venular constriction and dilation, respectively. Phenylephrine constricted and nitroglycerin dilated pial arterioles and venules. Pentobarbital did not produce either burst suppression or an isoelectric electroencephalogram. The results confirm our hypothesis: clinically relevant concentrations of propofol, that is, approximately 10 mol/L, do not dilate pial arterioles or venules.
Authors:
Kazuhiro Shibuya; Tadahiko Ishiyama; Manabu Ichikawa; Hiroaki Sato; Katsumi Okuyama; Daniel I Sessler; Takashi Matsukawa
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  21     ISSN:  1537-1921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  40-6     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Intravenous / pharmacology*
Animals
Arterioles / drug effects
Blood Pressure / drug effects
Body Temperature / drug effects
Body Weight / drug effects
Capillaries / drug effects
Cerebral Veins / drug effects
Electroencephalography
Fat Emulsions, Intravenous / pharmacology
Heart Rate / drug effects
Nitroglycerin / pharmacology
Phenylephrine / pharmacology
Pia Mater / blood supply*
Propofol / pharmacology*
Rabbits
Regional Blood Flow / drug effects
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Venules / drug effects
Grant Support
ID/Acronym/Agency:
GM 061655/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Fat Emulsions, Intravenous; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 2078-54-8/Propofol; 55-63-0/Nitroglycerin; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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