| A diminished rate of "physiological decay" at noise offset contributes to age-related changes in temporal acuity in the CBA mouse model of presbycusis. | |
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MedLine Citation:
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PMID: 12880063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The persistence of afferent activity at stimulus offset was examined in mice as a function of age (experiment 1) and noise level (experiment 2), using a procedure devised by von Bekesy to study the physiological decay of afferent activity. Noise offset was presented from 1 to 10 ms (the temporal gap) prior to an acoustic startle stimulus, with an abrupt edge or a linear ramp having the duration of the gap. Noise offset inhibited the startle reflex, this effect declining with age. For young (2-3 months old) and "young-old" mice (18-19 months old), the abrupt offset was always more inhibitory than the ramp, even for the one millisecond gap. In "old-old" mice (24-26 months old) abrupt and ramped offsets were not different until the gap exceeded 4 ms. The behavioral difference between abrupt and ramped decay times did not depend on noise level in young mice (4-5 months old), though overall inhibition increased with level. These data indicate that temporal acuity as measured by this gap detection method is limited in very old mice by their reduced ability to follow the abrupt change in noise level at the beginning of the gap. |
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Authors:
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James R Ison; Paul Allen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 114 ISSN: 0001-4966 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-07-25 Completed Date: 2003-09-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 522-8 Citation Subset: IM |
Affiliation:
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Department of Brain and Cognitive Sciences, Meliora Hall, University of Rochester, Rochester, New York 14627, USA. ison@bcs.rochester.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Age Factors Animals Attention / physiology* Auditory Pathways / physiology Auditory Threshold / physiology Disease Models, Animal* Loudness Perception / physiology* Mice Mice, Inbred CBA Neural Inhibition / physiology Noise Perceptual Masking / physiology* Presbycusis / physiopathology* Psychoacoustics* Reaction Time / physiology Startle Reaction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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AG09524/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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