Document Detail

The dilemma of inherited dysfibrinogenemia during pregnancy.
MedLine Citation:
PMID:  23135383     Owner:  NLM     Status:  MEDLINE    
Inherited dysfibrinogenemia is a rare disorder caused by mutations in the fibrinogen gene, described in approximately 400 families to date. We present the case of a 20-year-old woman at 7 weeks of pregnancy with a history of two first-trimester spontaneous abortions and a family history of thrombotic events. Her testing revealed evidence of dysfibrinogenemia, necessitating multidisciplinary management planning including Hematology, OB-GYN, Maternal-Fetal Medicine, Blood Bank Services and Anesthesia. Antenatal care included a combination of intravenous fibrinogen infusions to maintain fibrinogen levels above 100 mg/dl and anticoagulation with low molecular weight heparin. She had an uneventful full-term delivery and continued fibrinogen infusions and thromboprophylaxis for 6 weeks postpartum. The combination of fibrinogen infusions and anticoagulation maintained the balance between bleeding and clotting in our patient during pregnancy. We recommend a multidisciplinary team approach for the management of dysfibrinogenemia during pregnancy to provide successful pregnancy outcomes.
Javier Munoz; Jessica Schering; Angela Lambing; Salena Neal; Gregory Goyert; Pooja M Green; Amr Hanbali; Sundara Raman; Philip Kuriakose
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  23     ISSN:  1473-5733     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-04-16     Revised Date:  2013-04-29    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  775-7     Citation Subset:  IM    
Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA.
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MeSH Terms
Afibrinogenemia / blood,  congenital,  drug therapy*,  genetics
Anticoagulants / therapeutic use*
Fibrinogen / therapeutic use*
Fibrinogens, Abnormal / genetics
Hemorrhage / prevention & control*
Heparin, Low-Molecular-Weight / therapeutic use*
Injections, Intravenous
Live Birth
Pregnancy Complications, Hematologic / prevention & control*
Thrombosis / prevention & control*
Young Adult
Reg. No./Substance:
0/Anticoagulants; 0/Fibrinogens, Abnormal; 0/Heparin, Low-Molecular-Weight; 9001-32-5/Fibrinogen
Comment In:
Blood Coagul Fibrinolysis. 2013 Apr;24(3):353-4   [PMID:  23518794 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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