Document Detail


Is digoxin really important in treatment of compensated heart failure? A placebo-controlled crossover study in patients with sinus rhythm.
MedLine Citation:
PMID:  7051826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the efficacy of digitalis in patients with chronic clinically compensated congestive heart failure and normal sinus rhythm, we performed a double-blind crossover study with digoxin and placebo in 30 consecutive outpatients fulfilling these criteria; serum digoxin levels, clinical symptoms and signs, and objective indexes of cardiac function were monitored. No patient's clinical condition deteriorated during three months of placebo administration. Discontinuation of digoxin resulted in a small increase in echocardiographically determined resting left ventricular end-diastolic dimension (1.8 +/- 0.6 mm, p less than 0.001) and a similar decrease in velocity of circumferential fiber shortening (-0.08 +/- 0.04 circ/sec, p less than 0.05) from the corresponding values of 55.8 +/- 2.3 mm and 0.90 +/- 0.08 circ/sec during digitalis therapy. Resting left ventricular ejection time and pre-ejection period were prolonged by digoxin withdrawal. Maximal exercise capacity was unchanged. No clinical exacerbation of heart failure attributable to digitalis withdrawal occurred over a follow-up period averaging 19 months. The results indicate that long-term digoxin therapy has only a minor effect on cardiac performance that is without apparent clinical importance in a representative population of ambulatory patients treated with cardiac glycosides.
Authors:
J L Fleg; S H Gottlieb; E G Lakatta
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  73     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-10-12     Completed Date:  1982-10-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure
Cardiac Volume
Clinical Trials as Topic
Digoxin / therapeutic use*
Double-Blind Method
Echocardiography
Female
Heart Failure / drug therapy*,  physiopathology
Heart Rate*
Humans
Male
Middle Aged
Physical Exertion
Stroke Volume
Grant Support
ID/Acronym/Agency:
2S07-RR-0556/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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