Document Detail


A diffusion tensor imaging study of white matter in early-onset schizophrenia.
MedLine Citation:
PMID:  17662964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Voxel-based analysis of diffusion tensor magnetic resonance imaging (DTI) data was used to examine white matter integrity in adolescents with early-onset schizophrenia (EOS), defined as schizophrenia beginning before the 18th birthday. METHODS: Nineteen patients with EOS, aged 13 to 19, were compared with 20 healthy volunteers matched for age, gender, and parental socioeconomic status. Diffusion tensor magnetic resonance imaging data were acquired on a GE Signa NVi 1.5 Tesla system (General Electric, Milwaukee, Wisconsin). Maps of fractional anisotropy (FA) were registered into standard space, and group differences were examined using a nonparametric statistical approach. RESULTS: In comparison with healthy participants, EOS patients had significantly lower FA in the white matter of the parietal association cortex bilaterally and in the left middle cerebellar penduncle. No areas with significantly higher FA in patients were identified. CONCLUSIONS: Parietal and cerebellar white matter abnormalities may contribute to the emergence of psychotic symptoms in adolescence.
Authors:
Marinos Kyriakopoulos; Nora S Vyas; Gareth J Barker; Xavier A Chitnis; Sophia Frangou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-30
Journal Detail:
Title:  Biological psychiatry     Volume:  63     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-12     Completed Date:  2008-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  519-23     Citation Subset:  IM    
Affiliation:
Section of Neurobiology of Psychosis, Centre for Neuroimaging Sciences, King's College London, Institute of Psychiatry, London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Anisotropy
Brain / pathology*
Cerebellum / pathology
Diffusion Magnetic Resonance Imaging*
Dominance, Cerebral / physiology
Female
Humans
Image Processing, Computer-Assisted*
Male
Nerve Fibers, Myelinated / pathology
Parietal Lobe / pathology
Reference Values
Schizophrenia / diagnosis*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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